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Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study.

MedStar author(s):

1945-4589

Name of journal: AgingAbstract: Telomere length, a marker of biological aging, has been associated with cardiovascular disease (CVD). Increased arterial stiffness, an indicator of arterial aging, predicts adverse CVD outcomes. However, the relationship between telomere length and arterial stiffness is less well studied. Here we examined the cross-sectional association between leukocyte telomere length (LTL) and arterial stiffness in 2,165 American Indians in the Strong Heart Family Study (SHFS). LTL was measured by qPCR. Arterial stiffness was assessed by stiffness index beta. The association between LTL and arterial stiffness was assessed by generalized estimating equation model, adjusting for sociodemographics (age, sex, education level), study site, metabolic factors (fasting glucose, lipids, systolic blood pressure, and kidney function), lifestyle (BMI, smoking, drinking, and physical activity), and prevalent CVD. Results showed that longer LTL was significantly associated with a decreased arterial stiffness (beta=-0.070, P=0.007). This association did not attenuate after further adjustment for hsCRP (beta=-0.071, P=0.005) or excluding participants with overt CVD (beta=-0.068, P=0.012), diabetes (beta=-0.070, P=0.005), or chronic kidney disease (beta=-0.090, P=0.001). In summary, shorter LTL was significantly associated with an increased arterial stiffness, independent of known risk factors. This finding may shed light on the potential role of biological aging in arterial aging in American Indians.All authors: Best LG, Blackburn E, Cole SA, Devereux RB, Howard BV, Lee ET, Lin J, Peng H, Roman MJ, Yeh F, Zhao J, Zhu YFiscal year: FY2017Digital Object Identifier:

https://dx.doi.org/10.18632/aging.101013

Date added to catalog: 2017-05-24

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Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	27540694	Available		27540694

Telomere length, a marker of biological aging, has been associated with cardiovascular disease (CVD). Increased arterial stiffness, an indicator of arterial aging, predicts adverse CVD outcomes. However, the relationship between telomere length and arterial stiffness is less well studied. Here we examined the cross-sectional association between leukocyte telomere length (LTL) and arterial stiffness in 2,165 American Indians in the Strong Heart Family Study (SHFS). LTL was measured by qPCR. Arterial stiffness was assessed by stiffness index beta. The association between LTL and arterial stiffness was assessed by generalized estimating equation model, adjusting for sociodemographics (age, sex, education level), study site, metabolic factors (fasting glucose, lipids, systolic blood pressure, and kidney function), lifestyle (BMI, smoking, drinking, and physical activity), and prevalent CVD. Results showed that longer LTL was significantly associated with a decreased arterial stiffness (beta=-0.070, P=0.007). This association did not attenuate after further adjustment for hsCRP (beta=-0.071, P=0.005) or excluding participants with overt CVD (beta=-0.068, P=0.012), diabetes (beta=-0.070, P=0.005), or chronic kidney disease (beta=-0.090, P=0.001). In summary, shorter LTL was significantly associated with an increased arterial stiffness, independent of known risk factors. This finding may shed light on the potential role of biological aging in arterial aging in American Indians.

English