Reference ranges for rotational thromboelastometry in male Sprague Dawley rats.

MedStar author(s):
Citation: Thrombosis Journal [Electronic Resource]. 15:31, 2017PMID: 29299031Institution: MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment: Firefighters' Burn and Surgical Research Laboratory | SurgeryForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: PubMed-not-MEDLINE -- Not indexedYear: 2017Local holdings: Available online through MWHC library: 2003 - presentISSN:
  • 1477-9560
Name of journal: Thrombosis journalAbstract: Background: A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup and pin system.Conclusions: These reference ranges can be used in future studies in rats to identify clinically significant coagulopathies.Methods: Reference values for coagulation parameters from forty-three animals were calculated using data obtained from the ROTEM delta hemostasis analyzer with the EXTEM test.Results: The following ranges, presented as the 2.5-97.5 percentiles, were established: CT [18-77], CFT [20-80], alpha [73-86], MCF [53-70], and ML [1-22], along with others.All authors: Bravo MC, Brummel-Ziedins KE, Carney BC, Chen JH, Cruz MV, Luker JN, Moffatt LT, Orfeo T, Shupp JWFiscal year: FY2018Digital Object Identifier: Date added to catalog: 2018-01-18
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 29299031 Available 29299031

Available online through MWHC library: 2003 - present

Background: A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup and pin system.

Conclusions: These reference ranges can be used in future studies in rats to identify clinically significant coagulopathies.

Methods: Reference values for coagulation parameters from forty-three animals were calculated using data obtained from the ROTEM delta hemostasis analyzer with the EXTEM test.

Results: The following ranges, presented as the 2.5-97.5 percentiles, were established: CT [18-77], CFT [20-80], alpha [73-86], MCF [53-70], and ML [1-22], along with others.

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