Platelet count and total and cause-specific mortality in the Women's Health Initiative.

MedStar author(s):
Citation: Annals of Epidemiology. 27(4):274-280, 2017 AprPMID: 28320576Institution: Washington Cancer InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Cause of Death | *Mortality | *Platelet Count | Aged | Coronary Disease/bl [Blood] | Coronary Disease/mo [Mortality] | Female | Humans | Middle Aged | Neoplasms/bl [Blood] | Neoplasms/mo [Mortality] | Platelet Count/sn [Statistics & Numerical Data] | Proportional Hazards Models | Women's Health/sn [Statistics & Numerical Data]Year: 2017ISSN:
  • 1047-2797
Name of journal: Annals of epidemiologyAbstract: CONCLUSIONS: In this large study of postmenopausal women, both low- and high-platelet counts were associated with total and cause-specific mortality.Copyright (c) 2017 Elsevier Inc. All rights reserved.METHODS: Platelet count was measured at baseline in 159,746 postmenopausal women and again in year 3 in 75,339 participants. Participants were followed for a median of 15.9 years. Cox proportional hazards models were used to estimate the relative mortality hazards associated with deciles of baseline platelet count and of the mean of baseline + year 3 platelet count.PURPOSE: We used data from the Women's Health Initiative to examine the association of platelet count with total mortality, coronary heart disease (CHD) mortality, cancer mortality, and non-CHD/noncancer mortality.RESULTS: Low and high deciles of both baseline and mean platelet count were positively associated with total mortality, CHD mortality, cancer mortality, and non-CHD/noncancer mortality. The association was robust and was not affected by adjustment for a number of potential confounding factors, exclusion of women with comorbidity, or allowance for reverse causality. Low- and high-platelet counts were associated with all four outcomes in never smokers, former smokers, and current smokers.All authors: Kabat GC, Kim MY, Lessin L, Lin J, Manson JE, Rohan TE, Verma AK, Wassertheil-Smoller SFiscal year: FY2017Digital Object Identifier: Date added to catalog: 2017-05-06
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Journal Article MedStar Authors Catalog Article 28320576 Available 28320576

CONCLUSIONS: In this large study of postmenopausal women, both low- and high-platelet counts were associated with total and cause-specific mortality.

Copyright (c) 2017 Elsevier Inc. All rights reserved.

METHODS: Platelet count was measured at baseline in 159,746 postmenopausal women and again in year 3 in 75,339 participants. Participants were followed for a median of 15.9 years. Cox proportional hazards models were used to estimate the relative mortality hazards associated with deciles of baseline platelet count and of the mean of baseline + year 3 platelet count.

PURPOSE: We used data from the Women's Health Initiative to examine the association of platelet count with total mortality, coronary heart disease (CHD) mortality, cancer mortality, and non-CHD/noncancer mortality.

RESULTS: Low and high deciles of both baseline and mean platelet count were positively associated with total mortality, CHD mortality, cancer mortality, and non-CHD/noncancer mortality. The association was robust and was not affected by adjustment for a number of potential confounding factors, exclusion of women with comorbidity, or allowance for reverse causality. Low- and high-platelet counts were associated with all four outcomes in never smokers, former smokers, and current smokers.

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