Vitamin C: The next step in sepsis management?. [Review]

MedStar author(s):
Citation: Journal of Critical Care. 43:230-234, 2018 Feb.PMID: 28934705Institution: MedStar Washington Hospital CenterDepartment: Emergency MedicineForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Ascorbic Acid/tu [Therapeutic Use] | *Critical Care | *Shock, Septic/dt [Drug Therapy] | Ascorbic Acid/ad [Administration & Dosage] | HumansYear: 2017Local holdings: Available online through MWHC library: 2012 - presentISSN:
  • 0883-9441
Name of journal: Journal of critical careAbstract: Sepsis is a life-threatening medical condition, affecting approximately 26 million people worldwide every year. The disease is a continuum, marked by dysregulated inflammation and hemodynamic instability leading to shock, multi-system organ dysfunction, and death. Over the past decades, there has been a focus on the early identification and treatment of sepsis primarily with bundled and goal directed therapy. Despite these advances, morbidity and mortality has remained high, prompting investigation into novel therapies. Vitamin C is a water-soluble vitamin that plays a role in mediating inflammation through antioxidant activities and is also important in the synthesis of cortisol, catecholamines, and vasopressin, which are key mediators in the disease process. Emerging evidence provides cursory data in support of the administration of vitamin C in addition to standard therapy to ameliorate the effects of inflammation and improve hemodynamic stability in patients with sepsis and septic shock; however, further evidence is needed to support this practice. This review discusses the physiologic role of vitamin C as well as the recent literature and evidence for the use of vitamin C in patients presenting with sepsis. Copyright (c) 2017 Elsevier Inc. All rights reserved.All authors: Mazer-Amirshahi M, Pourmand A, Teng JOriginally published: Journal of Critical Care. 43:230-234, 2017 Sep 18Fiscal year: FY2018Digital Object Identifier: Date added to catalog: 2017-09-29
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 28934705 Available 28934705

Available online through MWHC library: 2012 - present

Sepsis is a life-threatening medical condition, affecting approximately 26 million people worldwide every year. The disease is a continuum, marked by dysregulated inflammation and hemodynamic instability leading to shock, multi-system organ dysfunction, and death. Over the past decades, there has been a focus on the early identification and treatment of sepsis primarily with bundled and goal directed therapy. Despite these advances, morbidity and mortality has remained high, prompting investigation into novel therapies. Vitamin C is a water-soluble vitamin that plays a role in mediating inflammation through antioxidant activities and is also important in the synthesis of cortisol, catecholamines, and vasopressin, which are key mediators in the disease process. Emerging evidence provides cursory data in support of the administration of vitamin C in addition to standard therapy to ameliorate the effects of inflammation and improve hemodynamic stability in patients with sepsis and septic shock; however, further evidence is needed to support this practice. This review discusses the physiologic role of vitamin C as well as the recent literature and evidence for the use of vitamin C in patients presenting with sepsis. Copyright (c) 2017 Elsevier Inc. All rights reserved.

English

Powered by Koha