MedStar Authors catalog › Details for: Hydroconductive and silver-impregnated foam dressings: a comparison.
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Hydroconductive and silver-impregnated foam dressings: a comparison.

by Alkhalil, Abdulnaser; Day, Anna; Monger, Kyle W; Zhang, J; Carney, Bonnie C; Hoffman, H N; Moffatt, Lauren T; Shupp, Jeffrey W.
Citation: Journal of Wound Care. 26(Sup7):S15-S22, 2017 Jul 01.Journal: Journal of wound care.Published: 2017ISSN: 0969-0700.Full author list: A A; A D; K W M; J Z; B C C; H N H; L T M; J W S.UI/PMID: 28704172.Subject(s): Animals | *Anti-Infective Agents, Local/pd [Pharmacology] | Bacterial Toxins/me [Metabolism] | *Bandages | Burns/mi [Microbiology] | *Burns/th [Therapy] | Enterotoxins/me [Metabolism] | In Vitro Techniques | *Methicillin-Resistant Staphylococcus aureus/de [Drug Effects] | Methicillin-Resistant Staphylococcus aureus/me [Metabolism] | Rats | *Silver/pd [Pharmacology] | *Staphylococcal Infections/th [Therapy] | Superantigens/de [Drug Effects] | Superantigens/me [Metabolism] | *Wound Healing/de [Drug Effects] | *Wound Infection/th [Therapy]Institution(s): MedStar Washington Hospital Center | MedStar Health Research InstituteDepartment(s): Burn and Surgical Research LaboratoryActivity type: Journal Article.Medline article type(s): Journal ArticleDigital Object Identifier: https://dx.doi.org/10.12968/jowc.2017.26.Sup7.S15 (Click here) Abbreviated citation: J Wound Care. 26(Sup7):S15-S22, 2017 Jul 01.Abstract: OBJECTIVE: As the number of commercially available wound dressings is increasing rapidly, it is important for clinicians to understand the strengths and limitations of each and to recognise relationships between wound type and dressing properties to obtain optimal healing results. Our aim is to test the antimicrobial activity of two dressings.Abstract: METHOD: A hydroconductive (HC) dressing and a silver-impregnated foam (SIF) dressing were compared for their potential to reduce the levels meticillin-resistant Staphylococcus aureus (MRSA). We also assessed MRSA-derived biologically active components in liquid or agar matrices, simplified models for heavily exuding or dry wounds respectively, and in an in vivo animal model with MRSA infected wounds.Abstract: RESULTS: In the agar model (dry wounds) both dressings showed a strong reduction in MRSA activities within 24 hours post-application. The antibacterial effects of the SIF dressing were more pronounced in the liquid model, however, at an increasing cytotoxic cost. In agreement with these in vitro results, assessment of dressings using an MRSA-infected wound in an rat model showed a decrease in MRSA which was significant 7 days post-burn and inoculation, with more compromised viability of MRSA. Dressings showed a similar capability to reduced and eliminate toxic shock syndrome toxin (TSST-1) at day 7 post-burn in the animal model but not at day 4, where the SIF dressing was more potent Conclusion: These results confirm the advantages of using silver in reducing bacterial load in wound treatment, except for conditions of highly exuding wounds where the cytotoxic properties of silver may offset these advantages and HC dressing use is more suitable.

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