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Hypothyroidism. [Review]

MedStar author(s):

Citation: Lancet. 390(10101):1550-1562, 2017 Sep 23.PMID: 28336049Institution: MedStar Washington Hospital CenterDepartment: Medicine/EndocrinologyForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Disease Management | *Hypothyroidism/di [Diagnosis] | *Hypothyroidism/dt [Drug Therapy] | *Thyroxine/tu [Therapeutic Use] | Hormone Replacement Therapy | Hypothyroidism/ep [Epidemiology] | Thyroxine/ae [Adverse Effects] | Thyroxine/df [Deficiency]Year: 2017 Local holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1983 - 2007ISSN:

0140-6736

Name of journal: Lancet (London, England)Abstract: Copyright (c) 2017 Elsevier Ltd. All rights reserved.Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate. Clinical manifestations of hypothyroidism range from life threatening to no signs or symptoms. The most common symptoms in adults are fatigue, lethargy, cold intolerance, weight gain, constipation, change in voice, and dry skin, but clinical presentation can differ with age and sex, among other factors. The standard treatment is thyroid hormone replacement therapy with levothyroxine. However, a substantial proportion of patients who reach biochemical treatment targets have persistent complaints. In this Seminar, we discuss the epidemiology, causes, and symptoms of hypothyroidism; summarise evidence on diagnosis, long-term risk, treatment, and management; and highlight future directions for research.All authors: Bianco AC, Chaker L, Jonklaas J, Peeters RPFiscal year: FY2018Digital Object Identifier:

https://dx.doi.org/10.1016/S0140-6736(17)30703-1

Date added to catalog: 2018-11-02

Holdings ( 1 )
Title notes ( 4 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	28336049	Available		28336049

Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1983 - 2007

Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate. Clinical manifestations of hypothyroidism range from life threatening to no signs or symptoms. The most common symptoms in adults are fatigue, lethargy, cold intolerance, weight gain, constipation, change in voice, and dry skin, but clinical presentation can differ with age and sex, among other factors. The standard treatment is thyroid hormone replacement therapy with levothyroxine. However, a substantial proportion of patients who reach biochemical treatment targets have persistent complaints. In this Seminar, we discuss the epidemiology, causes, and symptoms of hypothyroidism; summarise evidence on diagnosis, long-term risk, treatment, and management; and highlight future directions for research.

English