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Genetic aberrations and alterations in signaling cascades implicated in the pathogenesis of anaplastic thyroid cancer. [Review]

MedStar author(s):

Citation: Biochimica et Biophysica Acta - Reviews on Cancer. 2018 Dec 31PMID: 30605717Institution: MedStar Washington Hospital CenterDepartment: Medicine/EndocrinologyForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: IN PROCESS -- NOT YET INDEXEDYear: 2018 ISSN:

0304-419X

Name of journal: Biochimica et biophysica acta. Reviews on cancerAbstract: Anaplastic Thyroid Cancer (ATC) accounts for >40% thyroid cancer-related deaths and has a dismal prognosis. In the past decade, significant efforts have been made towards understanding the pathogenesis of this disease and developing novel therapeutics. Unfortunately, effective treatment is still lacking and a more thorough understanding of ATC pathogenesis may provide new opportunities to improve ATC therapeutics. This review provides insights into ATC clinical presentation and pathology, and the putative role of genetic aberrations and alterations in molecular signaling pathways in ATC pathogenesis. We reviewed prevalent mutations, chromosomal abnormalities and fusions, epigenetic alterations and dysregulations in ATC, and have highlighted several signaling cascades which appear to be integral to ATC pathogenesis. Moreover, these features offer insights into de-differentiated, aggressive and drug-resistant phenotype of ATC, and thus may serve as a potential new molecular targets for developing novel therapeutics.Copyright (c) 2018. Published by Elsevier B.V.All authors: Burman KD, Maker AV, Prabhakar BS, Saini SFiscal year: FY2019Digital Object Identifier:

https://dx.doi.org/10.1016/j.bbcan.2018.12.003

Date added to catalog: 2019-01-18

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Title notes ( 3 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	30605717	Available		30605717

Anaplastic Thyroid Cancer (ATC) accounts for >40% thyroid cancer-related deaths and has a dismal prognosis. In the past decade, significant efforts have been made towards understanding the pathogenesis of this disease and developing novel therapeutics. Unfortunately, effective treatment is still lacking and a more thorough understanding of ATC pathogenesis may provide new opportunities to improve ATC therapeutics. This review provides insights into ATC clinical presentation and pathology, and the putative role of genetic aberrations and alterations in molecular signaling pathways in ATC pathogenesis. We reviewed prevalent mutations, chromosomal abnormalities and fusions, epigenetic alterations and dysregulations in ATC, and have highlighted several signaling cascades which appear to be integral to ATC pathogenesis. Moreover, these features offer insights into de-differentiated, aggressive and drug-resistant phenotype of ATC, and thus may serve as a potential new molecular targets for developing novel therapeutics.

English