Trajectories of maternal gestational weight gain and child cognition assessed at 5 years of age in a prospective cohort study.

MedStar author(s):
Citation: Journal of Epidemiology & Community Health. 70(7):696-703, 2016 07.PMID: 26759126Institution: MedStar Washington Hospital CenterDepartment: Obstetrics and Gynecology/Maternal-Fetal MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Child Development | *Intelligence | *Prenatal Exposure Delayed Effects | *Weight Gain | Child, Preschool | Cognition | Female | Humans | IN PROCESS -- NOT YET INDEXED | Pregnancy | Prospective StudiesYear: 2016Local holdings: Available online through MWHC library: 1947 - 2005ISSN:
  • 0143-005X
Name of journal: Journal of epidemiology and community healthAbstract: BACKGROUND: There has been concern that low gestational weight gain may cause poor fetal neurodevelopment.CONCLUSIONS: Our findings are reassuring that among normal weight women, pregnancy weight gain is not associated with child cognitive development. Further investigation should be conducted in contemporary cohorts that also include obese mothers, who are at the greatest risk for low weight gain.Copyright Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/METHODS: The association between maternal weight gain and child IQ was examined using serial antenatal weight measurements (median 12) from a prospective cohort of non-obese Scandinavian women (1986-1988). Linear mixed models with piecewise regression were used to estimate participants' (n=552) trimester-specific average rate of weight gain. Linear regression was used to assess the association between weight gain and children's (n=344) full-scale, performance and verbal IQ measured at age 5 using the Wechsler Preschool and Primary Scales of Intelligence-Revised.RESULTS: Children born to mothers who gained below versus within the 2nd trimester 2009 recommendations tended to have lower IQ scores (Full-scale: 106.6 (SD 15.1) vs 110.2 (15.2), p=0.04; verbal: 102.5 (14.3) vs 105.0 (14.9), p=0.10; performance: 109.5 (15.4) vs 113.4 (14.5), p=0.03). After adjustment there were no differences in child IQ by weight gain adequacy (full-scale: betabelow=-1.1 (95% CI -5.1 to 2.9), betaabove=1.5 (-3.8 to 6.8); verbal: betabelow=-0.2 (-3.1 to 2.6), betaabove=1.8 (-3.6 to 7.3); performance betabelow=-1.2 (-4.6 to 2.2), betaabove=1.0 (-4.6 to 6.7)). No differences were observed based on 3rd trimester adequacy. No differences were observed in IQ scores by quintile of weight gain for any trimester, particularly after adjustment for maternal IQ.All authors: Albert PS, Grantz KL, Grewal J, Hinkle SN, Sjaarda LAFiscal year: FY2017Digital Object Identifier: Date added to catalog: 2019-01-18
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 26759126 Available 26759126

Available online through MWHC library: 1947 - 2005

BACKGROUND: There has been concern that low gestational weight gain may cause poor fetal neurodevelopment.

CONCLUSIONS: Our findings are reassuring that among normal weight women, pregnancy weight gain is not associated with child cognitive development. Further investigation should be conducted in contemporary cohorts that also include obese mothers, who are at the greatest risk for low weight gain.

Copyright Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

METHODS: The association between maternal weight gain and child IQ was examined using serial antenatal weight measurements (median 12) from a prospective cohort of non-obese Scandinavian women (1986-1988). Linear mixed models with piecewise regression were used to estimate participants' (n=552) trimester-specific average rate of weight gain. Linear regression was used to assess the association between weight gain and children's (n=344) full-scale, performance and verbal IQ measured at age 5 using the Wechsler Preschool and Primary Scales of Intelligence-Revised.

RESULTS: Children born to mothers who gained below versus within the 2nd trimester 2009 recommendations tended to have lower IQ scores (Full-scale: 106.6 (SD 15.1) vs 110.2 (15.2), p=0.04; verbal: 102.5 (14.3) vs 105.0 (14.9), p=0.10; performance: 109.5 (15.4) vs 113.4 (14.5), p=0.03). After adjustment there were no differences in child IQ by weight gain adequacy (full-scale: betabelow=-1.1 (95% CI -5.1 to 2.9), betaabove=1.5 (-3.8 to 6.8); verbal: betabelow=-0.2 (-3.1 to 2.6), betaabove=1.8 (-3.6 to 7.3); performance betabelow=-1.2 (-4.6 to 2.2), betaabove=1.0 (-4.6 to 6.7)). No differences were observed based on 3rd trimester adequacy. No differences were observed in IQ scores by quintile of weight gain for any trimester, particularly after adjustment for maternal IQ.

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