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Safety and long-term outcomes after percutaneous coronary intervention in patients with human immunodeficiency virus. []

by Badr, Salem; Minha, Sa'ar; Kitabata, Hironori; Fatemi, Omid; Torguson, Rebecca; Suddath, William O; Satler, Lowell F; Pichard, Augusto D; Waksman, Ron.
Citation: Catheterization & Cardiovascular Interventions. 85(2):192-8, 2015 Feb 1..Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.ISSN: 1522-1946.Full author list: Badr S; Minha S; Kitabata H; Fatemi O; Torguson R; Suddath WO; Satler LF; Pichard AD; Waksman R.UI/PMID: 24585520.Subject(s): Aged | Chi-Square Distribution | Coronary Artery Disease/co [Complications] | Coronary Artery Disease/di [Diagnosis] | Coronary Artery Disease/mo [Mortality] | *Coronary Artery Disease/th [Therapy] | Databases, Factual | Drug-Eluting Stents | Female | *HIV Infections/co [Complications] | HIV Infections/di [Diagnosis] | HIV Infections/mo [Mortality] | Humans | Kaplan-Meier Estimate | Male | Middle Aged | Multivariate Analysis | Myocardial Infarction/et [Etiology] | Odds Ratio | Patient Selection | Percutaneous Coronary Intervention/ae [Adverse Effects] | Percutaneous Coronary Intervention/is [Instrumentation] | Percutaneous Coronary Intervention/mo [Mortality] | *Percutaneous Coronary Intervention | Proportional Hazards Models | Retrospective Studies | Risk Assessment | Risk Factors | Time Factors | Treatment OutcomeInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Observational StudyOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.1002/ccd.25466 (Click here) Abbreviated citation: Catheter Cardiovasc Interv. 85(2):192-8, 2015 Feb 1.Local Holdings: Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1996 - 2006.Abstract: OBJECTIVE: This study aims to report the long-term outcomes after percutaneous coronary intervention (PCI) in human immunodeficiency virus (HIV+) patients.Abstract: BACKGROUND: Sparse data exists regarding the risk of patients with HIV who undergo PCI.Abstract: METHODS: Using a case-control design, we compared baseline characteristics, procedure-related outcomes, in-hospital, and 2-year clinical outcomes of 112 consecutive HIV+ patients versus 112 HIV- controls matched for age, gender, and diabetes mellitus who underwent PCI from April 2003 to September 2011.Abstract: RESULTS: Baseline characteristics were generally comparable, save for more African Americans and history of chronic renal insufficiency in the HIV+ vs. HIV- group (62.5% vs. 21.4%, P < 0.001) and (27.7% vs. 9.9%, P < 0.001). There was no correlation between CD4 nadir count and extent and diffuseness of coronary artery disease. The occurrence of major adverse cardiac events at 2 years was similar in both groups. Multivariable analysis for independent correlates of major adverse cardiac events at 2 years detected patients with a history of chronic renal insufficiency (OR: 2.44, 95% confidence interval: 1.02-5.83; P = 0.04) and acute myocardial infarction (OR: 2.92, 95% confidence interval: 1.39-6.15; P = 0.005) as correlates for outcome. Post-hoc analysis showed that drug-eluting stent (DES) use in the HIV+ group was beneficial.Abstract: CONCLUSION: PCI in HIV+ patients is safe, with high procedural success rates, and produces similar outcomes to those seen in HIV- patients at 2 years. HIV+ patients should be treated with DES if possible.Copyright � 2014 Wiley Periodicals, Inc.

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