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Sex-Associated Differences in Cardiac Reverse Remodeling in Patients Supported by Contemporary Left Ventricular Assist Devices.

MedStar author(s):

Afari-Armah, Nana

Boyce, Steven W

Citation: Journal of Cardiac Failure. 26(6):494-504, 2020 Jun.PMID: 32200097Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Heart Failure | *Heart-Assist Devices | Female | Heart Failure/dg [Diagnostic Imaging] | Heart Failure/th [Therapy] | Hemodynamics | Humans | Male | Middle Aged | Sex Characteristics | Ventricular Function, Left | Ventricular RemodelingYear: 2020 Local holdings: Available online from MWHC library: 1995 - presentISSN:

1071-9164

Name of journal: Journal of cardiac failureAbstract: BACKGROUND: Women differ from men in their left ventricular (LV) structure, function, and remodeling with age and diseases. The LV assist device (LVAD) unloads the LV and reversely remodels the heart. We sought to define the effects of sex on longitudinal reverse remodeling after LVAD implantation.CONCLUSION: Women had significantly more favorable longitudinal changes in cardiac structure and function in response to LV unloading compared with men. Understanding the cause of sex difference in reverse remodeling after LVAD may help devise novel therapeutic strategies for women with advanced HF. Copyright (c) 2020. Published by Elsevier Inc.METHODS: Cardiac structure and function were assessed by serial echocardiograms. Mixed effect regression models were constructed to assess the independent contribution of sex to longitudinal changes in cardiac structure and function.RESULTS: A total of 355 consecutive patients with advanced heart failure (HF) received continuous flow LVADs between 2006 and 2016. The average age was 56+/-13 years, 73% were men and 67% were black. Early (within 3 months) after LVAD implantation, women had a greater reduction in LV dimensions and a greater increase in LV ejection fraction compared with men. These differences were independent of age, BSA, device type or ischemic etiology of HF. At long-term follow-up, LV dimensions increased slightly over time in women compared with men, but overall earlier changes were maintained.All authors: Afari-Armah N, Boyce S, Hofmeyer M, Kenigsberg BB, Majure DT, Mohammed SF, Molina EJ, Najjar SS, Rodrigo M, Sheikh FH, Wang ZOriginally published: Journal of Cardiac Failure. 2020 Mar 18Fiscal year: FY2020Digital Object Identifier:

https://dx.doi.org/10.1016/j.cardfail.2020.03.005

Date added to catalog: 2020-07-09

Holdings ( 1 )
Title notes ( 6 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	32200097	Available		32200097

Available online from MWHC library: 1995 - present

BACKGROUND: Women differ from men in their left ventricular (LV) structure, function, and remodeling with age and diseases. The LV assist device (LVAD) unloads the LV and reversely remodels the heart. We sought to define the effects of sex on longitudinal reverse remodeling after LVAD implantation.

CONCLUSION: Women had significantly more favorable longitudinal changes in cardiac structure and function in response to LV unloading compared with men. Understanding the cause of sex difference in reverse remodeling after LVAD may help devise novel therapeutic strategies for women with advanced HF. Copyright (c) 2020. Published by Elsevier Inc.

METHODS: Cardiac structure and function were assessed by serial echocardiograms. Mixed effect regression models were constructed to assess the independent contribution of sex to longitudinal changes in cardiac structure and function.

RESULTS: A total of 355 consecutive patients with advanced heart failure (HF) received continuous flow LVADs between 2006 and 2016. The average age was 56+/-13 years, 73% were men and 67% were black. Early (within 3 months) after LVAD implantation, women had a greater reduction in LV dimensions and a greater increase in LV ejection fraction compared with men. These differences were independent of age, BSA, device type or ischemic etiology of HF. At long-term follow-up, LV dimensions increased slightly over time in women compared with men, but overall earlier changes were maintained.

English