Bacterial Virulence Factors and their Contribution to Pathophysiology after Thermal Injury.

MedStar author(s):
Citation: Surgical Infections. 22(1):69-76, 2021 Feb.PMID: 32735479Institution: MedStar Health Research InstituteDepartment: Firefighters' Burn and Surgical Research LaboratoryForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Burns | *Pseudomonas Infections | Bacteria | Burns/co [Complications] | Humans | Pseudomonas aeruginosa | Virulence | Virulence FactorsYear: 2021ISSN:
  • 1096-2964
Name of journal: Surgical infectionsAbstract: Background: Bacterial infections are the leading cause of morbidity and mortality in burn-injured patients. Pseudomonas aeruginosa and Staphylococcus aureus are among the most common pathogens responsible for infections in thermally injured patients. These and other pathogens have developed a variety of virulence factors to colonize and infect hosts. Methods: A comprehensive literature review was conducted to best summarize the current knowledge of how virulence factors contribute to bacterial pathogenicity. Results: The review highlights the unique mechanisms bacteria utilize to evade host defense systems and further complicate the treatment of burn-injured patients. Conclusion: Further research on virulence factors and their contribution to bacterial pathogenicity is warranted and could potentially lead to development of neutralizing pharmacotherapy that would complement antimicrobial treatment.All authors: Kirkpatrick LD, Nisar S, Shupp JWOriginally published: Surgical Infections. 2020 Jul 28Fiscal year: FY2021Fiscal year of original publication: FY2021Digital Object Identifier: Date added to catalog: 2020-09-02
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Journal Article MedStar Authors Catalog Article 32735479 Available 32735479

Background: Bacterial infections are the leading cause of morbidity and mortality in burn-injured patients. Pseudomonas aeruginosa and Staphylococcus aureus are among the most common pathogens responsible for infections in thermally injured patients. These and other pathogens have developed a variety of virulence factors to colonize and infect hosts. Methods: A comprehensive literature review was conducted to best summarize the current knowledge of how virulence factors contribute to bacterial pathogenicity. Results: The review highlights the unique mechanisms bacteria utilize to evade host defense systems and further complicate the treatment of burn-injured patients. Conclusion: Further research on virulence factors and their contribution to bacterial pathogenicity is warranted and could potentially lead to development of neutralizing pharmacotherapy that would complement antimicrobial treatment.

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