The spectrum of 124I uptake in the lacrimal gland and nasolacrimal sac/duct on PET/CT imaging.

MedStar author(s):
Citation: Nuclear Medicine Communications. 42(3):292-299, 2021 Mar 01.PMID: 33323865Institution: MedStar Washington Hospital CenterDepartment: Medicine/Endocrinology | Medicine/Nuclear MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Iodine Radioisotopes/me [Metabolism] | *Lacrimal Apparatus/dg [Diagnostic Imaging] | *Lacrimal Apparatus/me [Metabolism] | *Nasolacrimal Duct/dg [Diagnostic Imaging] | *Nasolacrimal Duct/me [Metabolism] | *Positron Emission Tomography Computed Tomography | Adult | Biological Transport | Female | Humans | Male | Middle Aged | Young AdultYear: 2021Local holdings: Available online through MWHC library: 2003 - presentISSN:
  • 0143-3636
Name of journal: Nuclear medicine communicationsAbstract: CONCLUSIONS: In patients with DTC, I activity in the NLDs is more frequently visualized, more intense, more prolonged, and more variable than in the lacrimal glands. The lack of clearance may suggest possible obstruction or stasis of an NLD.METHODS: I PET/CT in 31 DTC patients was performed at 2, 24, 48, 72, and 96 h after oral administration of 31.5 or 62.9 MBq (0.85 or 1.7 mCi) of I after either recombinant human thyroid-stimulating hormone injections or thyroid hormone withdrawal. All but two patients had a history of prior I therapy. Patterns of I uptake in the lacrimal glands and nasolacrimal sac/ducts (NLD) were assessed.RESULTS: A total of 173 individual I PET/CT scans (forming 35 sets of scans) were reviewed for 31 patients. Lacrimal glands were visualized bilaterally in only 4 patients. The focal mild uptake (grade 2), best seen on the 2-h images, was crescent-shaped and located in the lateral upper quadrant of the orbit. In contrast, the NLDs were identified in all patients (bilateral in 29 of 31 patients) with high focal uptake (grade 4) peaking on the 2- and 24-h timepoints; however, the overall pattern of uptake was variable. Of the 29 patients with prior I therapy, three patients had a relatively fixed and unchanging pattern of uptake on at least one side of the NLDs.This study characterizes the spectrum of physiologic I uptake of the lacrimal system in patients with a history of differentiated thyroid cancer (DTC) who underwent multi-timepoint I PET/CT imaging.All authors: Burman KD, Garcia C, Kulkarni K, Plyku D, Van Nostrand D, Wartofsky L, Wu DOriginally published: Nuclear Medicine Communications. 2020 Dec 14Fiscal year: FY2021Digital Object Identifier: Date added to catalog: 2020-12-31
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Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 33323865 Available 33323865

Available online through MWHC library: 2003 - present

CONCLUSIONS: In patients with DTC, I activity in the NLDs is more frequently visualized, more intense, more prolonged, and more variable than in the lacrimal glands. The lack of clearance may suggest possible obstruction or stasis of an NLD.

METHODS: I PET/CT in 31 DTC patients was performed at 2, 24, 48, 72, and 96 h after oral administration of 31.5 or 62.9 MBq (0.85 or 1.7 mCi) of I after either recombinant human thyroid-stimulating hormone injections or thyroid hormone withdrawal. All but two patients had a history of prior I therapy. Patterns of I uptake in the lacrimal glands and nasolacrimal sac/ducts (NLD) were assessed.

RESULTS: A total of 173 individual I PET/CT scans (forming 35 sets of scans) were reviewed for 31 patients. Lacrimal glands were visualized bilaterally in only 4 patients. The focal mild uptake (grade 2), best seen on the 2-h images, was crescent-shaped and located in the lateral upper quadrant of the orbit. In contrast, the NLDs were identified in all patients (bilateral in 29 of 31 patients) with high focal uptake (grade 4) peaking on the 2- and 24-h timepoints; however, the overall pattern of uptake was variable. Of the 29 patients with prior I therapy, three patients had a relatively fixed and unchanging pattern of uptake on at least one side of the NLDs.

This study characterizes the spectrum of physiologic I uptake of the lacrimal system in patients with a history of differentiated thyroid cancer (DTC) who underwent multi-timepoint I PET/CT imaging.

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