MedStar Authors catalog › Details for: Clearance of Hepatitis C Virus (HCV) Is Associated With Improved Outcomes in HCV-Associated Lymphoma.
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Clearance of Hepatitis C Virus (HCV) Is Associated With Improved Outcomes in HCV-Associated Lymphoma.

by Adhikari, Tripti; Al-Shbool, Ghassan; Baez-Sosa, Valentina; Desai, Sanjal; Fernandez, Stephen J; Fishbein, Dawn; Hameed, Rumaisa; Malkovska, Vera; Paku, Emily; Stingo, Facundo; Vakiti, Anusha.
Citation: Clinical lymphoma, myeloma & leukemia. 21(2):e185-e193, 2021 02.; .Journal: Clinical lymphoma, myeloma & leukemia.Published: 2021; ; ; ISSN: 2152-2669.Full author list: Adhikari T; Al-Shbool G; Baez-Sosa V; Desai SH; Fernandez S; Fishbein D; Hameed R; Malkovska V; Paku E; Stingo F; Vakiti A.UI/PMID: 33132102.Subject(s): *Antiviral Agents/tu [Therapeutic Use] | *Hepacivirus/ip [Isolation & Purification] | *Hepatitis C/dt [Drug Therapy] | *Lymphoma, Non-Hodgkin/mo [Mortality] | Adolescent | Adult | Aged | Aged, 80 and over | Female | Hepacivirus/ge [Genetics] | Hepatitis C/vi [Virology] | Humans | Lymphoma, Non-Hodgkin/th [Therapy] | Lymphoma, Non-Hodgkin/vi [Virology] | Male | Middle Aged | Progression-Free Survival | Retrospective Studies | RNA, Viral/ip [Isolation & Purification] | Young AdultInstitution(s): MedStar Health Research Institute | MedStar Heart & Vascular Institute | MedStar Washington Hospital Center | Washington Cancer Institute | Washington Cancer Institute HDepartment(s): Medicine/Infectious Diseases | Medicine/Internal MedicineActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: (Click here) Abbreviated citation: Clin Lymphoma Myeloma Leuk. 21(2):e185-e193, 2021 02; .Abstract: BACKGROUND: Improved hepatitis C virus (HCV) clearance due to directly acting antiviral agents has led to remarkably improved outcomes of indolent HCV-associated non-Hodgkin lymphoma (NHL). The impact of directly acting antivirals on the outcomes of aggressive NHL is still under investigation. Characteristics of HCV-associated NHL in black patients are not well characterized. We report outcomes of HCV-associated NHL compared to their HCV-negative counterparts in a predominantly black population.Abstract: CONCLUSION: HCV clearance is positively associated with lymphoma outcomes in black patients. Patients who clear HCV have noninferior outcomes to HCV- patients, while those who fail to clear HCV have significantly worse outcomes. Copyright (c) 2020 Elsevier Inc. All rights reserved.Abstract: PATIENTS AND METHODS: Patients with lymphoma between January 2007 and December 2017 were retrospectively studied. Depending on presence or absence of HCV RNA, patients were grouped into HCV positive (HCV+) and HCV negative (HCV-) cohorts. Depending on virologic clearance (VC), HCV+ were classified into HCV+ with VC and HCV+ without VC. Overall response rate (ORR), complete response, overall survival (OS), and progression-free survival (PFS) of HCV+ patients with and without VC were compared to HCV- patients.Abstract: RESULTS: Of 397 patients with lymphoma, 40 had HCV. Black comprised 90% of HCV+ patients. Diffuse large B-cell lymphoma was most frequent (47%) in the HCV+ group. HCV+ patients without VC had significantly worse OS and PFS compared to HCV- patients. There were no differences in ORR, complete response, PFS, and OS of HCV+ patients with VC and HCV- patients. These results were consistent in subgroups of diffuse large B-cell lymphoma and aggressive lymphoma.

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