Citation: Clinical lymphoma, myeloma & leukemia. 2020 Oct 02.Journal: Clinical lymphoma, myeloma & leukemia.Published: ; 2020ISSN: 2152-2669.Full author list: Desai SH; Baez-Sosa V; Hameed R; Al-Shbool G; Fernandez S; Vakiti A; Stingo F; Adhikari T; Paku E; Malkovska V; Fishbein D.UI/PMID: 33132102.Subject(s): IN PROCESS -- NOT YET INDEXEDInstitution(s): Washington Cancer Institute H | MedStar Washington Hospital Center | MedStar Heart & Vascular Institute | MedStar Health Research Institute | Washington Cancer InstituteDepartment(s): Medicine/Internal Medicine | Medicine/Infectious DiseasesActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access onlineDigital Object Identifier: https://dx.doi.org/10.1016/j.clml.2020.09.011 (Click here)Abbreviated citation: Clin Lymphoma Myeloma Leuk. 2020 Oct 02.Abstract: BACKGROUND: Improved hepatitis C virus (HCV) clearance due to directly acting antiviral agents has led to remarkably improved outcomes of indolent HCV-associated non-Hodgkin lymphoma (NHL). The impact of directly acting antivirals on the outcomes of aggressive NHL is still under investigation. Characteristics of HCV-associated NHL in black patients are not well characterized. We report outcomes of HCV-associated NHL compared to their HCV-negative counterparts in a predominantly black population.Abstract: PATIENTS AND METHODS: Patients with lymphoma between January 2007 and December 2017 were retrospectively studied. Depending on presence or absence of HCV RNA, patients were grouped into HCV positive (HCV+) and HCV negative (HCV-) cohorts. Depending on virologic clearance (VC), HCV+ were classified into HCV+ with VC and HCV+ without VC. Overall response rate (ORR), complete response, overall survival (OS), and progression-free survival (PFS) of HCV+ patients with and without VC were compared to HCV- patients.Abstract: RESULTS: Of 397 patients with lymphoma, 40 had HCV. Black comprised 90% of HCV+ patients. Diffuse large B-cell lymphoma was most frequent (47%) in the HCV+ group. HCV+ patients without VC had significantly worse OS and PFS compared to HCV- patients. There were no differences in ORR, complete response, PFS, and OS of HCV+ patients with VC and HCV- patients. These results were consistent in subgroups of diffuse large B-cell lymphoma and aggressive lymphoma.Abstract: CONCLUSION: HCV clearance is positively associated with lymphoma outcomes in black patients. Patients who clear HCV have noninferior outcomes to HCV- patients, while those who fail to clear HCV have significantly worse outcomes. Copyright (c) 2020 Elsevier Inc. All rights reserved.