An Assessment of Research Priorities to Dampen the Pendulum Swing of Burn Resuscitation.

MedStar author(s):
Citation: Journal of Burn Care & Research. 42(2):113-125, 2021 03 04.PMID: 33306095Institution: MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment: Firefighters' Burn and Surgical Research Laboratory | Surgery/Burn ServicesForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Burns/th [Therapy] | *Critical Care/st [Standards] | *Evidence-Based Medicine/st [Standards] | *Resuscitation/st [Standards] | Humans | Multiple Organ Failure/pc [Prevention & Control] | Research Design/st [Standards] | Shock, Traumatic/pc [Prevention & Control] | Societies, Medical/st [Standards]Year: 2021Local holdings: Available online through MWHC library: 2006 - present, Available in print through MWHC library: 2006 - presentISSN:
  • 1559-047X
Name of journal: Journal of burn care & research : official publication of the American Burn AssociationAbstract: On June 17-18, 2019, the American Burn Association, in conjunction with Underwriters Laboratories, convened a group of experts on burn and inhalation injury in Washington, DC. The goal of the meeting was to identify and discuss strategies to optimize the process of burn resuscitation. Patients who sustain a large thermal injury (involving >20% of the total body surface area [TBSA]) face a sequence of challenges, beginning with burn shock. Over the last century, research has helped elucidate much of the underlying pathophysiology of burn shock, which places multiple organ systems at risk of damage or dysfunction. These studies advanced the understanding of the optimal use of fluids for resuscitation. The resultant practice of judicious and timely infusion of crystalloids has likely improved mortality after major thermal injury. However, much remains unclear about how to further improve and customize resuscitation practice to limit the morbidities associated with edema and volume overload. Herein, we review the history and pathophysiology of shock following thermal injury, and propose some of the priorities for resuscitation research. Recommendations include: studying the utility of alternative endpoints to resuscitation, re-examining plasma as a primary or adjunctive resuscitation fluid, and applying information about inflammation and endotheliopathy to target the underlying causes of burn shock. Undoubtedly, these future research efforts will require a concerted effort from the burn and research communities. Copyright Published by Oxford University Press on behalf of the American Burn Association 2020.All authors: Burmeister DM, Cancio LC, Carlson DL, Chung KK, Hill DM, Kubasiak JC, Moffatt LT, Muthumalaiappan K, Shupp JW, Smith SL, Wade CEOriginally published: Journal of Burn Care & Research. 2020 Dec 11Fiscal year: FY2021Fiscal year of original publication: FY2021Digital Object Identifier: Date added to catalog: 2020-12-31
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 33306095 Available 33306095

Available online through MWHC library: 2006 - present, Available in print through MWHC library: 2006 - present

On June 17-18, 2019, the American Burn Association, in conjunction with Underwriters Laboratories, convened a group of experts on burn and inhalation injury in Washington, DC. The goal of the meeting was to identify and discuss strategies to optimize the process of burn resuscitation. Patients who sustain a large thermal injury (involving >20% of the total body surface area [TBSA]) face a sequence of challenges, beginning with burn shock. Over the last century, research has helped elucidate much of the underlying pathophysiology of burn shock, which places multiple organ systems at risk of damage or dysfunction. These studies advanced the understanding of the optimal use of fluids for resuscitation. The resultant practice of judicious and timely infusion of crystalloids has likely improved mortality after major thermal injury. However, much remains unclear about how to further improve and customize resuscitation practice to limit the morbidities associated with edema and volume overload. Herein, we review the history and pathophysiology of shock following thermal injury, and propose some of the priorities for resuscitation research. Recommendations include: studying the utility of alternative endpoints to resuscitation, re-examining plasma as a primary or adjunctive resuscitation fluid, and applying information about inflammation and endotheliopathy to target the underlying causes of burn shock. Undoubtedly, these future research efforts will require a concerted effort from the burn and research communities. Copyright Published by Oxford University Press on behalf of the American Burn Association 2020.

English

Powered by Koha