Spontaneous splenic rupture from indeterminate dendritic cell proliferation: a case report.

MedStar author(s):
Citation: Journal of Surgical Case Reports. 2022(6):rjac211, 2022 Jun.PMID: 35685294Institution: MedStar Franklin Square Medical Center | MedStar Union Memorial HospitalDepartment: Internal Medicine Residency | PathologyForm of publication: Journal ArticleMedline article type(s): Case ReportsYear: 2022ISSN:
  • 2042-8812
Name of journal: Journal of surgical case reportsAbstract: Spontaneous splenic rupture is a rare and life-threatening phenomenon, usually associated with an underlying infectious, inflammatory, hematological, neoplastic or rheumatologic condition. Indeterminate cell tumor is a rare neoplastic dendritic cell disorder that is poorly understood but shares immunophenotypic markers for Langerhans cells without Birbeck granules. A 73-year-old man presented with upper abdominal pain after an unwitnessed fall. Computed tomography angiography showed splenomegaly and a large ruptured splenic subcapsular hematoma. Intraoperative findings from an emergency laparotomy revealed a large hemoperitoneum and a ruptured spleen. Microscopic sections identified numerous, mostly poorly formed, small nodules classified as a proliferation of indeterminate dendritic cell tumors. Copyright Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2022.All authors: Bhansali D, Chittal AR, Iqbal SB, Lakra P, Pyrgos G, Rao SJFiscal year: FY2022Digital Object Identifier: ORCID: Date added to catalog: 2022-07-06
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Journal Article MedStar Authors Catalog Article 35685294 Available 35685294

Spontaneous splenic rupture is a rare and life-threatening phenomenon, usually associated with an underlying infectious, inflammatory, hematological, neoplastic or rheumatologic condition. Indeterminate cell tumor is a rare neoplastic dendritic cell disorder that is poorly understood but shares immunophenotypic markers for Langerhans cells without Birbeck granules. A 73-year-old man presented with upper abdominal pain after an unwitnessed fall. Computed tomography angiography showed splenomegaly and a large ruptured splenic subcapsular hematoma. Intraoperative findings from an emergency laparotomy revealed a large hemoperitoneum and a ruptured spleen. Microscopic sections identified numerous, mostly poorly formed, small nodules classified as a proliferation of indeterminate dendritic cell tumors. Copyright Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author(s) 2022.

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