Uric acid, hypertension, and chronic kidney disease among Alaska Eskimos: the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study.

MedStar author(s):
Citation: Journal of Clinical Hypertension. 14(2):71-7, 2012 Feb.PMID: 22277138Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., ExtramuralSubject headings: *Coronary Artery Disease/ep [Epidemiology] | *Coronary Artery Disease/ge [Genetics] | *Hypertension/bl [Blood] | *Hypertension/eh [Ethnology] | *Inuits | *Renal Insufficiency, Chronic/bl [Blood] | *Renal Insufficiency, Chronic/eh [Ethnology] | *Uric Acid/bl [Blood] | Adult | Alaska/ep [Epidemiology] | Female | Glomerular Filtration Rate | Humans | Linear Models | Logistic Models | Male | Middle Aged | Young AdultLocal holdings: Available online from MWHC library: 2001 - presentISSN:
  • 1524-6175
Name of journal: Journal of clinical hypertension (Greenwich, Conn.) Abstract: It is unknown what role uric acid (UA) may play in the increasing rates of cardiovascular disease (CVD) among Alaska Eskimos. UA is associated with both hypertension (HTN) and chronic kidney disease (CKD). The authors analyzed 1078 Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) participants. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine measures using the Modification of Diet in Renal Disease equation. CKD was defined by an eGFR of <60mL/min/1.73m(2) . The authors adjusted for age, sex, education, diabetes, hypertension (or eGFR), obesity, lipids, and smoking status; 7% (n=75) had prevalent CKD. eGFR decreased with increasing tertiles of serum UA (P<.001). UA was independently associated with prevalent CKD (adjusted odds ratio [OR] and 95% confidence interval [CI] of 2.04 (1.62-2.56), respectively). Twenty-one percent (n=230) had prevalent HTN and UA was independently associated with prevalent HTN (adjusted OR, 1.2; 95% CI, 1.1-1.5). UA is independently associated with prevalent CKD and HTN in this population. 2011 Wiley Periodicals, Inc.All authors: Comuzzie AG, Ebbesson SO, Howard BV, Jolly SE, Mete M, Umans JG, Voruganti VS, Wang H, Zhu JDigital Object Identifier: Date added to catalog: 2013-09-17
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article Available 22277138

Available online from MWHC library: 2001 - present

It is unknown what role uric acid (UA) may play in the increasing rates of cardiovascular disease (CVD) among Alaska Eskimos. UA is associated with both hypertension (HTN) and chronic kidney disease (CKD). The authors analyzed 1078 Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) participants. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine measures using the Modification of Diet in Renal Disease equation. CKD was defined by an eGFR of <60mL/min/1.73m(2) . The authors adjusted for age, sex, education, diabetes, hypertension (or eGFR), obesity, lipids, and smoking status; 7% (n=75) had prevalent CKD. eGFR decreased with increasing tertiles of serum UA (P<.001). UA was independently associated with prevalent CKD (adjusted odds ratio [OR] and 95% confidence interval [CI] of 2.04 (1.62-2.56), respectively). Twenty-one percent (n=230) had prevalent HTN and UA was independently associated with prevalent HTN (adjusted OR, 1.2; 95% CI, 1.1-1.5). UA is independently associated with prevalent CKD and HTN in this population. 2011 Wiley Periodicals, Inc.

English

Powered by Koha