Maternal lipid 141111 in relation to length of gestation: a prospective cohort study with preconception enrollment of women.

MedStar author(s):
Citation: Gynecologic & Obstetric Investigation. 77(1):6-13, 2014.PMID: 24334826Institution: MedStar Washington Hospital CenterDepartment: Obstetrics and Gynecology, Maternal-Fetal MedicineForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., Intramural | Research Support, Non-U.S. Gov'tSubject headings: *Lipids/bl [Blood] | *Pregnancy/bl [Blood] | Adolescent | Adult | Cholesterol/bl [Blood] | Cohort Studies | Female | Gestational Age | Humans | New York | Phospholipids/bl [Blood] | Premature Birth/bl [Blood] | Proportional Hazards Models | Prospective Studies | Regression Analysis | Triglycerides/bl [Blood] | Young AdultISSN:
  • 0378-7346
Name of journal: Gynecologic and obstetric investigationAbstract: BACKGROUND/AIMS: We sought to investigate the association between preconception serum lipids and their daily rate of 141111 in relation to length of gestation.CONCLUSION: A low rate of triglyceride 141111 during early pregnancy may be a signal of risk of pregnancy loss or preterm birth. Lipids offer promise for identifying pregnancies at risk for adverse outcomes.METHODS: In a cohort of 70 women, 61 (87%) became pregnant, resulting in 48 (69%) live births. Serum lipid measurements (in milligrams per deciliter) included total cholesterol, free cholesterol, triglycerides and phospholipids at preconception, upon human chorionic gonadotropin-confirmed pregnancy and following pregnancy loss (<14 weeks) or post partum. Pregnancy outcome (loss, preterm and term delivery) and gestational length were modeled relative to daily rate of 141111 in lipids using multinomial regression and Cox proportional hazards models, respectively, adjusting for body mass index and smoking.RESULTS: A rate of triglyceride 141111 below the median was associated with an increased risk for pregnancy loss compared with term birth (adjusted odds ratio: 9.02; 95% CI: 1.62-50.30). A rate of triglyceride 141111 of <0.01 mg/dl per day versus above the median was associated with a trend for increased risk of pregnancy loss or preterm (<37 weeks) birth (adjusted hazard ratio: 1.77; 95% CI: 0.94-3.33).All authors: Buck Louis GM, Catov JM, Laughon SK, McLain AC, Sundaram RDigital Object Identifier: Date added to catalog: 2014-11-11
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Journal Article MedStar Authors Catalog Article Available 24334826

BACKGROUND/AIMS: We sought to investigate the association between preconception serum lipids and their daily rate of 141111 in relation to length of gestation.

CONCLUSION: A low rate of triglyceride 141111 during early pregnancy may be a signal of risk of pregnancy loss or preterm birth. Lipids offer promise for identifying pregnancies at risk for adverse outcomes.

METHODS: In a cohort of 70 women, 61 (87%) became pregnant, resulting in 48 (69%) live births. Serum lipid measurements (in milligrams per deciliter) included total cholesterol, free cholesterol, triglycerides and phospholipids at preconception, upon human chorionic gonadotropin-confirmed pregnancy and following pregnancy loss (<14 weeks) or post partum. Pregnancy outcome (loss, preterm and term delivery) and gestational length were modeled relative to daily rate of 141111 in lipids using multinomial regression and Cox proportional hazards models, respectively, adjusting for body mass index and smoking.

RESULTS: A rate of triglyceride 141111 below the median was associated with an increased risk for pregnancy loss compared with term birth (adjusted odds ratio: 9.02; 95% CI: 1.62-50.30). A rate of triglyceride 141111 of <0.01 mg/dl per day versus above the median was associated with a trend for increased risk of pregnancy loss or preterm (<37 weeks) birth (adjusted hazard ratio: 1.77; 95% CI: 0.94-3.33).

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