Posttraumatic Stress Disorder Is Associated With a Decrease in Anaerobic Threshold, Oxygen Pulse, and Maximal Oxygen Uptake.

MedStar author(s):
Citation: Chest. 160(3):1017-1025, 2021 09.PMID: 33844979Institution: MedStar Washington Hospital CenterDepartment: MedicineForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Anaerobic Threshold | *Dyspnea | *Exercise | *Military Personnel | *Oximetry/mt [Methods] | *Oxygen Consumption | *Stress Disorders, Post-Traumatic | Adult | Dyspnea/di [Diagnosis] | Dyspnea/px [Psychology] | Exercise Test/mt [Methods] | Exercise/ph [Physiology] | Exercise/px [Psychology] | Female | Humans | Male | Military Personnel/px [Psychology] | Military Personnel/sn [Statistics & Numerical Data] | Respiratory Function Tests/mt [Methods] | Stress Disorders, Post-Traumatic/di [Diagnosis] | Stress Disorders, Post-Traumatic/ep [Epidemiology] | Stress Disorders, Post-Traumatic/pp [Physiopathology] | Symptom Assessment/mt [Methods] | Veterans HealthYear: 2021ISSN:
  • 0012-3692
Name of journal: ChestAbstract: BACKGROUND: Post-traumatic stress disorder (PTSD) has been linked to respiratory symptoms and functional limitations, but the mechanism(s) leading to this association are poorly defined.RESEARCH QUESTION: What is the relationship between PTSD, lung function, and the cardiopulmonary response to exercise in combat veterans presenting with chronic respiratory symptoms?RESULTS: 303 participants were included (PTSD =70; Non-PTSD =233). Those with PTSD had a greater frequency of current respiratory complaints. There were no differences in measures for airway disease or lung volumes, but patients with PTSD had a reduction in diffusing capacity (DLCO) that was eliminated after adjustment for differences in hemoglobin levels. Participants with PTSD had a lower anaerobic threshold (AT) (23.9 vs 26.4 cc/kg/min; p =0.004), peak oxygen pulse (19.7 vs 18.5 cc/beat; p=0.03) and peak oxygen uptake (peakVO2) (34.5 cc/kg/min vs 38.8 cc/kg/min, p <0.001). No significant difference was observed in gas-exchange, respiratory reserve, or effort at peak exercise between participants with and without PTSD. Copyright (c) 2021. Published by Elsevier Inc.STUDY DESIGN: and Methods: We prospectively enrolled military service members with respiratory symptoms following deployment to southwest Asia (SWA). All participants underwent a comprehensive evaluation to include pulmonary function (PFT) and cardiopulmonary exercise (CPET) testing. We compared PFT variables and cardiopulmonary response to exercise in subjects with and without PTSD using multivariable linear regression to adjust for confounders.All authors: Collen JF, Holley AB, McMahon MJ, Morris MJ, Sherner JH, Warren WA, Zeman JEOriginally published: Chest. 2021 Apr 09Chest. 160(3):1017-1025, 2021 09.Fiscal year: FY2022Fiscal year of original publication: FY2021Digital Object Identifier: Date added to catalog: 2021-06-07
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Journal Article MedStar Authors Catalog Article 33844979 Available 33844979

BACKGROUND: Post-traumatic stress disorder (PTSD) has been linked to respiratory symptoms and functional limitations, but the mechanism(s) leading to this association are poorly defined.

RESEARCH QUESTION: What is the relationship between PTSD, lung function, and the cardiopulmonary response to exercise in combat veterans presenting with chronic respiratory symptoms?

RESULTS: 303 participants were included (PTSD =70; Non-PTSD =233). Those with PTSD had a greater frequency of current respiratory complaints. There were no differences in measures for airway disease or lung volumes, but patients with PTSD had a reduction in diffusing capacity (DLCO) that was eliminated after adjustment for differences in hemoglobin levels. Participants with PTSD had a lower anaerobic threshold (AT) (23.9 vs 26.4 cc/kg/min; p =0.004), peak oxygen pulse (19.7 vs 18.5 cc/beat; p=0.03) and peak oxygen uptake (peakVO2) (34.5 cc/kg/min vs 38.8 cc/kg/min, p <0.001). No significant difference was observed in gas-exchange, respiratory reserve, or effort at peak exercise between participants with and without PTSD. Copyright (c) 2021. Published by Elsevier Inc.

STUDY DESIGN: and Methods: We prospectively enrolled military service members with respiratory symptoms following deployment to southwest Asia (SWA). All participants underwent a comprehensive evaluation to include pulmonary function (PFT) and cardiopulmonary exercise (CPET) testing. We compared PFT variables and cardiopulmonary response to exercise in subjects with and without PTSD using multivariable linear regression to adjust for confounders.

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