Efficacy and toxicity of sorafenib in the treatment of advanced medullary thyroid carcinoma: A systematic review and meta-analysis. [Review]
Citation: Head & Neck. 41(8):2823-2829, 2019 08.PMID: 31162772Institution: MedStar Union Memorial HospitalDepartment: MedicineForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Antineoplastic Agents/tu [Therapeutic Use] | *Carcinoma, Neuroendocrine/dt [Drug Therapy] | *Sorafenib/tu [Therapeutic Use] | *Thyroid Neoplasms/dt [Drug Therapy] | Antineoplastic Agents/ae [Adverse Effects] | Carcinoma, Neuroendocrine/sc [Secondary] | Humans | Sorafenib/ae [Adverse Effects] | Thyroid Neoplasms/sc [Secondary]Year: 2019Local holdings: Available online from MWHC library: 1996 - presentISSN:- 1043-3074
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 31162772 | Available | 31162772 |
Available online from MWHC library: 1996 - present
CONCLUSION: Our results show that sorafenib treatment has a modest effect and might be a candidate treatment in patients with metastatic MTCs who have failed other therapeutic regimens.
Copyright (c) 2019 Wiley Periodicals, Inc.
INTRODUCTION: The aim of this study is to investigate and summarize the treatment efficacy and adverse effects (AEs) of sorafenib in the treatment of metastatic medullary thyroid carcinomas (MTCs).
METHODS: We included studies reporting the treatment efficacy or drug toxicity of sorafenib as a single therapeutic agent in MTCs. Pooled incidence and its 95% confidence interval (CI) for complete response, partial response (PR), stable disease (SD), and sorafenib-related AEs were calculated using random-effect model.
RESULTS: Eight trials with 101 metastatic MTCs were included for meta-analyses. The overall PR and SD were 21% (95% CI = 9-33) and 58% (95% CI = 41-75), respectively. Hand-foot syndrome, diarrhea, alopecia, mucositis, skin rash, fatigue, and hypertension were the most commonly observed AEs.
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