MARC details
| 000 -LEADER |
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| fixed length control field |
03268nam a22005657a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
201231s20202020 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1559-047X |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1093/jbcr/iraa209 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
6029941 [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
33301570 |
| 245 ## - TITLE STATEMENT |
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| Title |
Cutaneous Thermal Injury Modulates Blood and Skin Metabolomes Differently in a Murine Model. |
| 251 ## - Source |
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| Source |
Journal of Burn Care & Research. 42(4):727-742, 2021 08 04. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
J Burn Care Res. 42(4):727-742, 2021 08 04. |
| 252 ## - Abbreviated Source |
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| Former abbreviated source |
J Burn Care Res. 2020 Dec 10 |
| 253 ## - Journal Name |
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| Journal name |
Journal of burn care & research : official publication of the American Burn Association |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2021 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2022 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
ppublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2020-12-31 |
| 268 ## - Previous citation |
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| -- |
Journal of Burn Care & Research. 2020 Dec 10 |
| 269 ## - Original dates |
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| Original fiscal year |
FY2021 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online through MWHC library: 2006 - present, Available in print through MWHC library: 2006 - present |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
As the field of metabolomics develops further, investigations of how the metabolome is affected following thermal injury may be helpful to inform diagnostics and guide treatments. In this study changes to the metabolome were tested and validated in a murine burn injury model. After a 30% total body surface scald injury or sham procedure sera and skin biopsies were collected at 1, 2, 6, or 24 hours. Burn-specific changes in the metabolome were detected compared to sham animals. The sera metabolome exhibited a more rapid response to burn injury than that of the skin and it peaked more proximal to injury (6 vs 24 hours). Progression of metabolic response in the skin was less synchronous and showed a higher overlap of the significantly modified metabolites (SMMs) among tested time-points. Top affected pathways identified by SMMs of skin included inositol phosphate metabolism, ascorbate and alderate metabolism, caffeine metabolism, and the pentose phosphate pathway. Future research is warranted in human and larger animal models to further elucidate the role of metabolomic perturbations and the pathophysiology following burn injury. Copyright (c) The Author(s) 2020. Published by Oxford University Press on behalf of the American Burn Association. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Biomarkers/me [Metabolism] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Burns/me [Metabolism] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Hot Temperature |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Metabolome |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Animals |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Burns/pa [Pathology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Disease Models, Animal |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Metabolomics/mt [Methods] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Mice |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Firefighters' Burn and Surgical Research Laboratory |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Surgery/Burn Services |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Alkhalil, Abdulnaser |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Ball, Robert |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Carney, Bonnie C |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Garg, Gaurav |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Moffatt, Lauren T |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Shupp, Jeffrey W |
| 790 ## - Authors |
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| All authors |
Alkhalil A, Ball RL, Carney BC, Day A, Garg G, Hammamieh R, Kumar R, Moffatt LT, Shupp JW |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1093/jbcr/iraa209">https://dx.doi.org/10.1093/jbcr/iraa209</a> |
| Public note |
https://dx.doi.org/10.1093/jbcr/iraa209 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
