Characterizing upper extremity motor behavior in the first week after stroke.
Characterizing upper extremity motor behavior in the first week after stroke.
- 2020
BACKGROUND: Animal models of brain recovery identify the first days after lesioning as a time of great flux in sensorimotor function and physiology. After rodent motor system lesioning, daily skill training in the less affected forelimb reduces skill acquisition in the more affected forelimb. We asked whether spontaneous human motor behaviors of the less affected upper extremity (UE) early after stroke resemble the animal training model, with the potential to suppress clinical recovery. CONCLUSIONS: Early after stroke, spontaneous overall UE movement is reduced, and movement shifts to unilateral use of the non-paretic UE. Two mechanisms that could influence motor recovery may already be in place 4.5 +/- 1.8 days post stroke: (1) the overuse of the less affected UE, which could set the stage for learned non-use and (2) skill acquisition in the non-paretic limb that could impede recovery. Accurate UE motor assessment requires two independent constructs: motor performance and quantity of movement. These findings provide opportunities and measurement methods for studies to develop new behaviorally-based stroke recovery treatments that begin early after onset. METHODS: This prospective observational study used a convenience sample of patients (n = 25, mean 4.5 +/-1.8) days after stroke with a wide severity range; Controls were hospitalized for non-neurological conditions (n = 12). Outcome measures were Accelerometry, Upper-Extremity Fugl-Meyer (UEFM), Action Research Arm Test (ARAT), Shoulder Abduction/ Finger Extension Test (SAFE), NIH Stroke Scale (NIHSS). RESULTS: Accelerometry indicated total paretic UE movement was reduced compared to controls, primarily due to a 44% reduction of bilateral UE use. Unilateral paretic movement was unchanged. Thus, movement shifted early after stroke; bilateral use was reduced and unilateral use of the non-paretic UE was increased by 77%. Low correlations between movement time and motor performance prompted an exploratory factor analysis (EFA) revealing a 2-component solution; motor performance tests load on one component (motor performance) whereas accelerometry-derived variables load on a second orthogonal component (quantity of movement).
English
1932-6203
10.1371/journal.pone.0221668 [doi] PMC7416933 [pmc] PONE-D-19-22340 [pii]
*Motor Activity/ph [Physiology]
*Stroke Rehabilitation/mt [Methods]
*Stroke/pp [Physiopathology]
Accelerometry/mt [Methods]
Aged
Female
Humans
Male
Middle Aged
Motor Skills/ph [Physiology]
Movement/ph [Physiology]
Outcome Assessment, Health Care
Paresis/pp [Physiopathology]
Paresis/th [Therapy]
Prospective Studies
Recovery of Function/ph [Physiology]
Time Factors
United States
Upper Extremity/ph [Physiology]
MedStar National Rehabilitation Network
Journal Article
BACKGROUND: Animal models of brain recovery identify the first days after lesioning as a time of great flux in sensorimotor function and physiology. After rodent motor system lesioning, daily skill training in the less affected forelimb reduces skill acquisition in the more affected forelimb. We asked whether spontaneous human motor behaviors of the less affected upper extremity (UE) early after stroke resemble the animal training model, with the potential to suppress clinical recovery. CONCLUSIONS: Early after stroke, spontaneous overall UE movement is reduced, and movement shifts to unilateral use of the non-paretic UE. Two mechanisms that could influence motor recovery may already be in place 4.5 +/- 1.8 days post stroke: (1) the overuse of the less affected UE, which could set the stage for learned non-use and (2) skill acquisition in the non-paretic limb that could impede recovery. Accurate UE motor assessment requires two independent constructs: motor performance and quantity of movement. These findings provide opportunities and measurement methods for studies to develop new behaviorally-based stroke recovery treatments that begin early after onset. METHODS: This prospective observational study used a convenience sample of patients (n = 25, mean 4.5 +/-1.8) days after stroke with a wide severity range; Controls were hospitalized for non-neurological conditions (n = 12). Outcome measures were Accelerometry, Upper-Extremity Fugl-Meyer (UEFM), Action Research Arm Test (ARAT), Shoulder Abduction/ Finger Extension Test (SAFE), NIH Stroke Scale (NIHSS). RESULTS: Accelerometry indicated total paretic UE movement was reduced compared to controls, primarily due to a 44% reduction of bilateral UE use. Unilateral paretic movement was unchanged. Thus, movement shifted early after stroke; bilateral use was reduced and unilateral use of the non-paretic UE was increased by 77%. Low correlations between movement time and motor performance prompted an exploratory factor analysis (EFA) revealing a 2-component solution; motor performance tests load on one component (motor performance) whereas accelerometry-derived variables load on a second orthogonal component (quantity of movement).
English
1932-6203
10.1371/journal.pone.0221668 [doi] PMC7416933 [pmc] PONE-D-19-22340 [pii]
*Motor Activity/ph [Physiology]
*Stroke Rehabilitation/mt [Methods]
*Stroke/pp [Physiopathology]
Accelerometry/mt [Methods]
Aged
Female
Humans
Male
Middle Aged
Motor Skills/ph [Physiology]
Movement/ph [Physiology]
Outcome Assessment, Health Care
Paresis/pp [Physiopathology]
Paresis/th [Therapy]
Prospective Studies
Recovery of Function/ph [Physiology]
Time Factors
United States
Upper Extremity/ph [Physiology]
MedStar National Rehabilitation Network
Journal Article