The association between a medical history of depression and gestational diabetes in a large multi-ethnic cohort in the United States.
The association between a medical history of depression and gestational diabetes in a large multi-ethnic cohort in the United States.
BACKGROUND: Both major depression and gestational diabetes mellitus (GDM) are prevalent among women of reproductive age. Our objective was to determine whether a medical history of depression is related to subsequent development of GDM. CONCLUSIONS: A history of depression was significantly associated with an increased GDM risk among a large multi-ethnic US cohort of women. If the association is confirmed, depression presents a potentially modifiable risk factor of GDM and provides additional clues to the underlying pathophysiology of GDM. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. METHODS: The Consortium on Safe Labor was a US retrospective cohort study of 228,562 births between 2002 and 2008. Exclusion criteria for the present analysis included multiple gestation pregnancies (n=5059), pre-existing diabetes (n=12,771), deliveries <24 weeks (n=395), site GDM prevalence (<1%) (n=20,721) and missing data on pre-pregnancy body mass index (BMI) (n=61,321). Using generalised estimating equations, we estimated the association between a history of depression and a pregnancy complicated by GDM. RESULTS: The final analytic population included 121,260 women contributing 128295 pregnancies, of which 5606 were affected by GDM. A history of depression was significantly associated with an increased risk of developing GDM (multivariate odds ratio [aOR]=1.42 [95% confidence interval (CI) 1.26, 1.60]). Adjusting for pre-pregnancy BMI and weight gain during pregnancy attenuated the association, although it remained statistically significant (aOR=1.17 [95% CI 1.03, 1.33]).
English
0269-5022
*Depressive Disorder/eh [Ethnology]
*Diabetes, Gestational/eh [Ethnology]
Adult
Cohort Studies
Continental Population Groups
Ethnic Groups
Female
Humans
Odds Ratio
Pregnancy
Retrospective Studies
Risk Factors
Socioeconomic Factors
United States/ep [Epidemiology]
Young Adult
MedStar Washington Hospital Center
Obstetrics and Gynecology, Maternal-Fetal Medicine
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
BACKGROUND: Both major depression and gestational diabetes mellitus (GDM) are prevalent among women of reproductive age. Our objective was to determine whether a medical history of depression is related to subsequent development of GDM. CONCLUSIONS: A history of depression was significantly associated with an increased GDM risk among a large multi-ethnic US cohort of women. If the association is confirmed, depression presents a potentially modifiable risk factor of GDM and provides additional clues to the underlying pathophysiology of GDM. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. METHODS: The Consortium on Safe Labor was a US retrospective cohort study of 228,562 births between 2002 and 2008. Exclusion criteria for the present analysis included multiple gestation pregnancies (n=5059), pre-existing diabetes (n=12,771), deliveries <24 weeks (n=395), site GDM prevalence (<1%) (n=20,721) and missing data on pre-pregnancy body mass index (BMI) (n=61,321). Using generalised estimating equations, we estimated the association between a history of depression and a pregnancy complicated by GDM. RESULTS: The final analytic population included 121,260 women contributing 128295 pregnancies, of which 5606 were affected by GDM. A history of depression was significantly associated with an increased risk of developing GDM (multivariate odds ratio [aOR]=1.42 [95% confidence interval (CI) 1.26, 1.60]). Adjusting for pre-pregnancy BMI and weight gain during pregnancy attenuated the association, although it remained statistically significant (aOR=1.17 [95% CI 1.03, 1.33]).
English
0269-5022
*Depressive Disorder/eh [Ethnology]
*Diabetes, Gestational/eh [Ethnology]
Adult
Cohort Studies
Continental Population Groups
Ethnic Groups
Female
Humans
Odds Ratio
Pregnancy
Retrospective Studies
Risk Factors
Socioeconomic Factors
United States/ep [Epidemiology]
Young Adult
MedStar Washington Hospital Center
Obstetrics and Gynecology, Maternal-Fetal Medicine
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural