High rate of microbleed formation following primary intracerebral hemorrhage.
High rate of microbleed formation following primary intracerebral hemorrhage.
- 2015
AIMS AND/OR HYPOTHESIS: To investigate the frequency and predictors of new microbleeds following intracerebral hemorrhage. BACKGROUND: We sought to investigate the frequency of microbleed development following intracerebral hemorrhage in a predominantly African-American population and to identify predictors of new microbleed formation. CONCLUSIONS: We found that one-third of intracerebral hemorrhage subjects in this cohort surviving one-year developed new microbleeds, which suggests a dynamic and rapidly progressive vasculopathy. Future studies are needed to examine the impact of new microbleed formation on patient outcomes.Copyright (c) 2015 World Stroke Organization. METHODS: The DECIPHER study was a prospective, longitudinal, magnetic resonance-based cohort study designed to evaluate racial/ethnic differences in risk factors for microbleeds and to evaluate the prognostic impact of microbleeds in this intracerebral hemorrhage population. We evaluated new microbleed formation in two time periods: from baseline to 30 days and from 30 days to year 1. RESULTS: Of 200 subjects enrolled in DECIPHER, 84 had magnetic resonance imaging at all required time points to meet criteria for this analysis. In the baseline to day 30 analysis, 11 (13.1%) had new microbleeds, compared with 25 (29.8%) in the day 30 to year 1 analysis. Logistic regression analysis demonstrated that baseline number of microbleeds [odds ratio 1.05 (95% confidence interval 1.01, 1.08), P=0.01] was associated with new microbleed formation at 30 days. A logistic regression model predicting new microbleed at one-year included baseline number of microbleeds [odds ratio 1.05 (1.00, 1.11), P=0.046], baseline age [odds ratio 1.05 (1.00, 1.10), P=0.04], and white matter disease score [odds ratio 1.18 (0.96, 1.45). P=0.115]. Overall, 28 of 84 (33.3%) intracerebral hemorrhage subjects formed new microbleeds at some point in the first year post-intracerebral hemorrhage.
English
1747-4930
*Intracranial Hemorrhages/et [Etiology]
*Stroke/co [Complications]
Brain/pa [Pathology]
Female
Humans
Intracranial Hemorrhages/di [Diagnosis]
Intracranial Hemorrhages/eh [Ethnology]
Intracranial Hemorrhages/pa [Pathology]
Logistic Models
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Multivariate Analysis
Prognosis
Prospective Studies
Risk Factors
Stroke/di [Diagnosis]
Stroke/eh [Ethnology]
Stroke/pa [Pathology]
Time Factors
United States/ep [Epidemiology]
MedStar Health Research Institute
MedStar Washington Hospital Center
MedStar Heart Institute
Journal Article
AIMS AND/OR HYPOTHESIS: To investigate the frequency and predictors of new microbleeds following intracerebral hemorrhage. BACKGROUND: We sought to investigate the frequency of microbleed development following intracerebral hemorrhage in a predominantly African-American population and to identify predictors of new microbleed formation. CONCLUSIONS: We found that one-third of intracerebral hemorrhage subjects in this cohort surviving one-year developed new microbleeds, which suggests a dynamic and rapidly progressive vasculopathy. Future studies are needed to examine the impact of new microbleed formation on patient outcomes.Copyright (c) 2015 World Stroke Organization. METHODS: The DECIPHER study was a prospective, longitudinal, magnetic resonance-based cohort study designed to evaluate racial/ethnic differences in risk factors for microbleeds and to evaluate the prognostic impact of microbleeds in this intracerebral hemorrhage population. We evaluated new microbleed formation in two time periods: from baseline to 30 days and from 30 days to year 1. RESULTS: Of 200 subjects enrolled in DECIPHER, 84 had magnetic resonance imaging at all required time points to meet criteria for this analysis. In the baseline to day 30 analysis, 11 (13.1%) had new microbleeds, compared with 25 (29.8%) in the day 30 to year 1 analysis. Logistic regression analysis demonstrated that baseline number of microbleeds [odds ratio 1.05 (95% confidence interval 1.01, 1.08), P=0.01] was associated with new microbleed formation at 30 days. A logistic regression model predicting new microbleed at one-year included baseline number of microbleeds [odds ratio 1.05 (1.00, 1.11), P=0.046], baseline age [odds ratio 1.05 (1.00, 1.10), P=0.04], and white matter disease score [odds ratio 1.18 (0.96, 1.45). P=0.115]. Overall, 28 of 84 (33.3%) intracerebral hemorrhage subjects formed new microbleeds at some point in the first year post-intracerebral hemorrhage.
English
1747-4930
*Intracranial Hemorrhages/et [Etiology]
*Stroke/co [Complications]
Brain/pa [Pathology]
Female
Humans
Intracranial Hemorrhages/di [Diagnosis]
Intracranial Hemorrhages/eh [Ethnology]
Intracranial Hemorrhages/pa [Pathology]
Logistic Models
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Multivariate Analysis
Prognosis
Prospective Studies
Risk Factors
Stroke/di [Diagnosis]
Stroke/eh [Ethnology]
Stroke/pa [Pathology]
Time Factors
United States/ep [Epidemiology]
MedStar Health Research Institute
MedStar Washington Hospital Center
MedStar Heart Institute
Journal Article