High rate of microbleed formation following primary intracerebral hemorrhage.

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Citation: International Journal of Stroke. 10(8):1187-91, 2015 Dec.PMID: 26311530Institution: MedStar Health Research Institute | MedStar Washington Hospital CenterDepartment: MedStar Heart InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Intracranial Hemorrhages/et [Etiology] | *Stroke/co [Complications] | Brain/pa [Pathology] | Female | Humans | Intracranial Hemorrhages/di [Diagnosis] | Intracranial Hemorrhages/eh [Ethnology] | Intracranial Hemorrhages/pa [Pathology] | Logistic Models | Longitudinal Studies | Magnetic Resonance Imaging | Male | Middle Aged | Multivariate Analysis | Prognosis | Prospective Studies | Risk Factors | Stroke/di [Diagnosis] | Stroke/eh [Ethnology] | Stroke/pa [Pathology] | Time Factors | United States/ep [Epidemiology]Year: 2015ISSN:
  • 1747-4930
Name of journal: International journal of stroke : official journal of the International Stroke SocietyAbstract: AIMS AND/OR HYPOTHESIS: To investigate the frequency and predictors of new microbleeds following intracerebral hemorrhage.BACKGROUND: We sought to investigate the frequency of microbleed development following intracerebral hemorrhage in a predominantly African-American population and to identify predictors of new microbleed formation.CONCLUSIONS: We found that one-third of intracerebral hemorrhage subjects in this cohort surviving one-year developed new microbleeds, which suggests a dynamic and rapidly progressive vasculopathy. Future studies are needed to examine the impact of new microbleed formation on patient outcomes.Copyright (c) 2015 World Stroke Organization.METHODS: The DECIPHER study was a prospective, longitudinal, magnetic resonance-based cohort study designed to evaluate racial/ethnic differences in risk factors for microbleeds and to evaluate the prognostic impact of microbleeds in this intracerebral hemorrhage population. We evaluated new microbleed formation in two time periods: from baseline to 30 days and from 30 days to year 1.RESULTS: Of 200 subjects enrolled in DECIPHER, 84 had magnetic resonance imaging at all required time points to meet criteria for this analysis. In the baseline to day 30 analysis, 11 (13.1%) had new microbleeds, compared with 25 (29.8%) in the day 30 to year 1 analysis. Logistic regression analysis demonstrated that baseline number of microbleeds [odds ratio 1.05 (95% confidence interval 1.01, 1.08), P=0.01] was associated with new microbleed formation at 30 days. A logistic regression model predicting new microbleed at one-year included baseline number of microbleeds [odds ratio 1.05 (1.00, 1.11), P=0.046], baseline age [odds ratio 1.05 (1.00, 1.10), P=0.04], and white matter disease score [odds ratio 1.18 (0.96, 1.45). P=0.115]. Overall, 28 of 84 (33.3%) intracerebral hemorrhage subjects formed new microbleeds at some point in the first year post-intracerebral hemorrhage.All authors: Burgess RE, Edwards DF, Fernandez S, Gibbons MC, Jayam-Trouth A, Kidwell CS, Mackey J, Menon RS, Norato G, Russell L, Shara NM, Sobotka I, Wing JJFiscal year: 2016Digital Object Identifier: Date added to catalog: 2017-03-06
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Journal Article MedStar Authors Catalog Article 26311530 Available 26311530

AIMS AND/OR HYPOTHESIS: To investigate the frequency and predictors of new microbleeds following intracerebral hemorrhage.

BACKGROUND: We sought to investigate the frequency of microbleed development following intracerebral hemorrhage in a predominantly African-American population and to identify predictors of new microbleed formation.

CONCLUSIONS: We found that one-third of intracerebral hemorrhage subjects in this cohort surviving one-year developed new microbleeds, which suggests a dynamic and rapidly progressive vasculopathy. Future studies are needed to examine the impact of new microbleed formation on patient outcomes.Copyright (c) 2015 World Stroke Organization.

METHODS: The DECIPHER study was a prospective, longitudinal, magnetic resonance-based cohort study designed to evaluate racial/ethnic differences in risk factors for microbleeds and to evaluate the prognostic impact of microbleeds in this intracerebral hemorrhage population. We evaluated new microbleed formation in two time periods: from baseline to 30 days and from 30 days to year 1.

RESULTS: Of 200 subjects enrolled in DECIPHER, 84 had magnetic resonance imaging at all required time points to meet criteria for this analysis. In the baseline to day 30 analysis, 11 (13.1%) had new microbleeds, compared with 25 (29.8%) in the day 30 to year 1 analysis. Logistic regression analysis demonstrated that baseline number of microbleeds [odds ratio 1.05 (95% confidence interval 1.01, 1.08), P=0.01] was associated with new microbleed formation at 30 days. A logistic regression model predicting new microbleed at one-year included baseline number of microbleeds [odds ratio 1.05 (1.00, 1.11), P=0.046], baseline age [odds ratio 1.05 (1.00, 1.10), P=0.04], and white matter disease score [odds ratio 1.18 (0.96, 1.45). P=0.115]. Overall, 28 of 84 (33.3%) intracerebral hemorrhage subjects formed new microbleeds at some point in the first year post-intracerebral hemorrhage.

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