The association between hemoglobin concentration and neurologic outcome after cardiac arrest.
The association between hemoglobin concentration and neurologic outcome after cardiac arrest.
- 2016
Available online through MWHC library: 2012 - present
CONCLUSION: Higher Hgb after cardiac arrest is associated with favorable neurologic outcome, particularly within the first 6 hours. It is unclear if this effect is due to impaired oxygen delivery or if Hgb is a marker for more severe illness. Copyright (c) 2016 Elsevier Inc. All rights reserved. METHODS: We conducted a retrospective cohort study using the Penn Alliance for Therapeutic Hypothermia (PATH) cardiac arrest registry. Inclusion criteria were resuscitated cardiac arrest (inhospital or out of hospital) and an Hgb value recorded within 24 hours of return of spontaneous circulation. The primary outcome was favorable neurologic status at hospital discharge. Survival to hospital discharge was a secondary outcome. PURPOSE: The purpose of the study is to determine the association between hemoglobin concentration (Hgb) and neurologic outcome in postarrest patients. RESULTS: There were 598 eligible patients from 21 hospitals. Patients with favorable neurologic outcome had significantly higher median Hgb in the first 2 hours (12.7 vs 10.5 g/dL; P<.001) and 6 hours (12.6 vs 10.6 g/dL; P<.001) postarrest. Controlling for age, pulseless rhythm, etiology, location of arrest, receipt of targeted temperature management, hematologic or metastatic malignancy, or preexisting renal insufficiency, there was a significant relationship between Hgb and neurologic outcome within the first 6 hours after arrest (odds ratio, 1.23; 95% confidence interval, 1.09-1.38) and survival to hospital discharge (odds ratio, 1.20; 95% confidence interval, 1.08-1.34).
English
0883-9441
*Anemia/ep [Epidemiology]
*Cardiopulmonary Resuscitation/mt [Methods]
*Heart Arrest/th [Therapy]
*Hemoglobins/me [Metabolism]
*Hypothermia, Induced/mt [Methods]
*Hypoxia, Brain/pp [Physiopathology]
*Registries
Adult
Aged
Aged, 80 and over
Anemia/me [Metabolism]
Cohort Studies
Comorbidity
Female
Heart Arrest/co [Complications]
Heart Arrest/ep [Epidemiology]
Heart Arrest/me [Metabolism]
Humans
Hypoxia, Brain/et [Etiology]
Male
Middle Aged
Neoplasms/ep [Epidemiology]
Odds Ratio
Renal Insufficiency/ep [Epidemiology]
Retrospective Studies
Survival Rate
Treatment Outcome
MedStar Washington Hospital Center
Emergency Medicine
Journal Article
Available online through MWHC library: 2012 - present
CONCLUSION: Higher Hgb after cardiac arrest is associated with favorable neurologic outcome, particularly within the first 6 hours. It is unclear if this effect is due to impaired oxygen delivery or if Hgb is a marker for more severe illness. Copyright (c) 2016 Elsevier Inc. All rights reserved. METHODS: We conducted a retrospective cohort study using the Penn Alliance for Therapeutic Hypothermia (PATH) cardiac arrest registry. Inclusion criteria were resuscitated cardiac arrest (inhospital or out of hospital) and an Hgb value recorded within 24 hours of return of spontaneous circulation. The primary outcome was favorable neurologic status at hospital discharge. Survival to hospital discharge was a secondary outcome. PURPOSE: The purpose of the study is to determine the association between hemoglobin concentration (Hgb) and neurologic outcome in postarrest patients. RESULTS: There were 598 eligible patients from 21 hospitals. Patients with favorable neurologic outcome had significantly higher median Hgb in the first 2 hours (12.7 vs 10.5 g/dL; P<.001) and 6 hours (12.6 vs 10.6 g/dL; P<.001) postarrest. Controlling for age, pulseless rhythm, etiology, location of arrest, receipt of targeted temperature management, hematologic or metastatic malignancy, or preexisting renal insufficiency, there was a significant relationship between Hgb and neurologic outcome within the first 6 hours after arrest (odds ratio, 1.23; 95% confidence interval, 1.09-1.38) and survival to hospital discharge (odds ratio, 1.20; 95% confidence interval, 1.08-1.34).
English
0883-9441
*Anemia/ep [Epidemiology]
*Cardiopulmonary Resuscitation/mt [Methods]
*Heart Arrest/th [Therapy]
*Hemoglobins/me [Metabolism]
*Hypothermia, Induced/mt [Methods]
*Hypoxia, Brain/pp [Physiopathology]
*Registries
Adult
Aged
Aged, 80 and over
Anemia/me [Metabolism]
Cohort Studies
Comorbidity
Female
Heart Arrest/co [Complications]
Heart Arrest/ep [Epidemiology]
Heart Arrest/me [Metabolism]
Humans
Hypoxia, Brain/et [Etiology]
Male
Middle Aged
Neoplasms/ep [Epidemiology]
Odds Ratio
Renal Insufficiency/ep [Epidemiology]
Retrospective Studies
Survival Rate
Treatment Outcome
MedStar Washington Hospital Center
Emergency Medicine
Journal Article