Non-Cytotoxic Related Primary Ovarian Insufficiency in Adolescents: Multicenter Case Series and Review.
Non-Cytotoxic Related Primary Ovarian Insufficiency in Adolescents: Multicenter Case Series and Review.
- 2018
Available online through MWHC library: 2002 - present
CONCLUSIONS: Non-cytotoxic POI in adolescents is an uncommon condition with only 64 cases in 6 institutions over 7 years. These patients may not undergo complete etiological workup. Aside from 45X, the most common etiologies are X-chromosome abnormalities or galactosemia. Copyright (c) 2018 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved. DESIGN: Case series of patients with POI. INTERVENTIONS: Review and data extraction of records identified with ICD-9 and ICD-10 codes. MAIN OUTCOME MEASURE(S): Data were analyzed for signs and symptoms, workup, and treatments. Complete work-up was based on ACOG guidelines. Characteristics of patients with POI presenting with delayed puberty/primary amenorrhea vs secondary amenorrhea were compared. RESULTS: 135 records were identified. Those who had received cytotoxic therapy (n=52), 46XY gonadal dysgenesis (n=7),or on review did not have POI (n=19) were excluded. Of 57 remaining cases, 16 were 45X, 2 had galactosemia and 4 had X-chromosome abnormalities. Most did not undergo full etiologic evaluation. Girls diagnosed following primary amenorrhea/delayed puberty were less symptomatic and more likely to receive an estrogen patch than those diagnosed following secondary amenorrhea. SETTING: Six tertiary care institutions ParticipantsPatients presenting from 2007-2014 aged 13-21 years diagnosed with non-cytotoxic POI, exclusions gonadotoxic therapy, 46XY gonadal dysgenesis, lack of evidence of hypergonadotropic hypogonadism on chart review. STUDY OBJECTIVE: Primary ovarian insufficiency (POI) in adolescents not due to cytotoxic therapy has not been well studied. Causes of POI have been described in adults, but adolescents may represent a unique subset necessitating a targeted approach to diagnosis, work-up and treatment. We sought to better characterize adolescent POI through a descriptive multicenter study.
English
1083-3188
10.1016/j.jpag.2018.06.006 [doi] S1083-3188(18)30247-X [pii]
*Primary Ovarian Insufficiency/et [Etiology]
Adolescent
Amenorrhea/et [Etiology]
Female
Gonadal Dysgenesis/co [Complications]
Humans
Puberty, Delayed/et [Etiology]
Young Adult
MedStar Washington Hospital Center
Obstetrics and Gynecology/Pediatric and Adolescent
Journal Article
Available online through MWHC library: 2002 - present
CONCLUSIONS: Non-cytotoxic POI in adolescents is an uncommon condition with only 64 cases in 6 institutions over 7 years. These patients may not undergo complete etiological workup. Aside from 45X, the most common etiologies are X-chromosome abnormalities or galactosemia. Copyright (c) 2018 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved. DESIGN: Case series of patients with POI. INTERVENTIONS: Review and data extraction of records identified with ICD-9 and ICD-10 codes. MAIN OUTCOME MEASURE(S): Data were analyzed for signs and symptoms, workup, and treatments. Complete work-up was based on ACOG guidelines. Characteristics of patients with POI presenting with delayed puberty/primary amenorrhea vs secondary amenorrhea were compared. RESULTS: 135 records were identified. Those who had received cytotoxic therapy (n=52), 46XY gonadal dysgenesis (n=7),or on review did not have POI (n=19) were excluded. Of 57 remaining cases, 16 were 45X, 2 had galactosemia and 4 had X-chromosome abnormalities. Most did not undergo full etiologic evaluation. Girls diagnosed following primary amenorrhea/delayed puberty were less symptomatic and more likely to receive an estrogen patch than those diagnosed following secondary amenorrhea. SETTING: Six tertiary care institutions ParticipantsPatients presenting from 2007-2014 aged 13-21 years diagnosed with non-cytotoxic POI, exclusions gonadotoxic therapy, 46XY gonadal dysgenesis, lack of evidence of hypergonadotropic hypogonadism on chart review. STUDY OBJECTIVE: Primary ovarian insufficiency (POI) in adolescents not due to cytotoxic therapy has not been well studied. Causes of POI have been described in adults, but adolescents may represent a unique subset necessitating a targeted approach to diagnosis, work-up and treatment. We sought to better characterize adolescent POI through a descriptive multicenter study.
English
1083-3188
10.1016/j.jpag.2018.06.006 [doi] S1083-3188(18)30247-X [pii]
*Primary Ovarian Insufficiency/et [Etiology]
Adolescent
Amenorrhea/et [Etiology]
Female
Gonadal Dysgenesis/co [Complications]
Humans
Puberty, Delayed/et [Etiology]
Young Adult
MedStar Washington Hospital Center
Obstetrics and Gynecology/Pediatric and Adolescent
Journal Article