Clinical features of hypertriglyceridemia-induced acute pancreatitis in an international, multicenter, prospective cohort (APPRENTICE consortium).
Clinical features of hypertriglyceridemia-induced acute pancreatitis in an international, multicenter, prospective cohort (APPRENTICE consortium).
- 2020
BACKGROUND: The clinical features and outcomes of hypertriglyceridemia-induced acute pancreatitis (HTG-AP) are not well-established. CONCLUSION: HTG-AP was found to be the 4th most common etiology of AP. HTG-AP patients had distinct baseline characteristics, but their clinical outcomes were similar compared to other etiologies of AP. Copyright (c) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved. METHODS: Data collection was conducted prospectively through APPRENTICE between 2015 and 2018. HTG-AP was defined as serum TG levels >500 mg/dl in the absence of other common etiologies of AP. Three multivariate logistic regression models were performed to assess whether HTG-AP is associated with SIRS positive status, ICU admission and/or moderately-severe/severe AP. OBJECTIVE: To evaluate the clinical characteristics of HTG-AP in an international, multicenter prospective cohort. RESULTS: 1,478 patients were included in the study; 69 subjects (4.7%) were diagnosed with HTG-AP. HTG-AP patients were more likely to be younger (mean 40 vs 50 years; p < 0.001), male (67% vs 52%; p = 0.018), and with a higher BMI (mean 30.4 vs 27.5 kg/m2; p = 0.0002). HTG-AP subjects reported more frequent active alcohol use (71% vs 49%; p < 0.001), and diabetes mellitus (59% vs 15%; p < 0.001). None of the above risk factors/variables was found to be independently associated with SIRS positive status, ICU admission, or severity in the multivariate logistic regression models. These results were similar when including only the 785 subjects with TG levels measured within 48 h from admission.
English
1424-3903
10.1016/j.pan.2020.02.010 [doi] S1424-3903(20)30046-6 [pii]
*Hypertriglyceridemia/co [Complications]
*Pancreatitis/et [Etiology]
*Pancreatitis/pp [Physiopathology]
Adult
Age Factors
Aged
Alcohol Drinking
Body Mass Index
Critical Care
Diabetes Complications
Female
Humans
Hypertriglyceridemia/ep [Epidemiology]
Male
Middle Aged
Pancreatitis/th [Therapy]
Prevalence
Prospective Studies
Registries
Risk Factors
Triglycerides/bl [Blood]
MedStar Georgetown University Hospital Residents
Journal Article
BACKGROUND: The clinical features and outcomes of hypertriglyceridemia-induced acute pancreatitis (HTG-AP) are not well-established. CONCLUSION: HTG-AP was found to be the 4th most common etiology of AP. HTG-AP patients had distinct baseline characteristics, but their clinical outcomes were similar compared to other etiologies of AP. Copyright (c) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved. METHODS: Data collection was conducted prospectively through APPRENTICE between 2015 and 2018. HTG-AP was defined as serum TG levels >500 mg/dl in the absence of other common etiologies of AP. Three multivariate logistic regression models were performed to assess whether HTG-AP is associated with SIRS positive status, ICU admission and/or moderately-severe/severe AP. OBJECTIVE: To evaluate the clinical characteristics of HTG-AP in an international, multicenter prospective cohort. RESULTS: 1,478 patients were included in the study; 69 subjects (4.7%) were diagnosed with HTG-AP. HTG-AP patients were more likely to be younger (mean 40 vs 50 years; p < 0.001), male (67% vs 52%; p = 0.018), and with a higher BMI (mean 30.4 vs 27.5 kg/m2; p = 0.0002). HTG-AP subjects reported more frequent active alcohol use (71% vs 49%; p < 0.001), and diabetes mellitus (59% vs 15%; p < 0.001). None of the above risk factors/variables was found to be independently associated with SIRS positive status, ICU admission, or severity in the multivariate logistic regression models. These results were similar when including only the 785 subjects with TG levels measured within 48 h from admission.
English
1424-3903
10.1016/j.pan.2020.02.010 [doi] S1424-3903(20)30046-6 [pii]
*Hypertriglyceridemia/co [Complications]
*Pancreatitis/et [Etiology]
*Pancreatitis/pp [Physiopathology]
Adult
Age Factors
Aged
Alcohol Drinking
Body Mass Index
Critical Care
Diabetes Complications
Female
Humans
Hypertriglyceridemia/ep [Epidemiology]
Male
Middle Aged
Pancreatitis/th [Therapy]
Prevalence
Prospective Studies
Registries
Risk Factors
Triglycerides/bl [Blood]
MedStar Georgetown University Hospital Residents
Journal Article