MARC details
| 000 -LEADER |
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| fixed length control field |
02502nam a22003137a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
220511s20222022 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1523-0864 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1089/ars.2022.0029 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
35350849 |
| 245 ## - TITLE STATEMENT |
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| Title |
High level of selenium exposure in the Strong Heart Study: a cause for incident cardiovascular disease?. |
| 251 ## - Source |
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| Source |
Antioxidants & Redox Signaling. 2022 Mar 30 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Antioxid Redox Signal. 2022 Mar 30 |
| 253 ## - Journal Name |
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| Journal name |
Antioxidants & redox signaling |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2022 Mar 30 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2022-05-11 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Increasing evidence suggests that high selenium (Se) exposure is associated with adverse health effects. However, limited evidence exists on the association of Se exposure with cardiovascular disease (CVD), especially in communities affected by high naturally occurring Se in environmental media. We evaluated the prospective association between urinary Se levels and CVD incidence and mortality for 2,727 American Indian adults who participated in the Strong Heart Study, with urinary Se levels measured at baseline (1989-1991) and CVD outcomes ascertained through 2017. The median (interquartile range) of urinary Se was 49.0 (36.7, 67.4) microg/g creatinine. The multivariable adjusted hazard ratios (95%CI) of incident CVD, coronary heart disease, and stroke comparing the 75th vs. 25th percentile of urinary Se distributions were 1.11 (1.01, 1.22), 1.05 (0.94, 1.17), and 1.08 (0.88, 1.33), respectively. In flexible dose-response models, increased risk for CVD incidence was only observed when urinary Se level exceeded 60 microg/g creatinine. For CVD mortality, a non-statistically significant U-shaped relationship was found across urinary Se levels. There was no evidence of effect modification by other urinary metal/metalloid levels. Our observation leads to the hypothesis that elevated Se exposure is a risk factor for CVD, especially in Se-replete populations. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Umans, Jason G |
| 790 ## - Authors |
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| All authors |
Ali T, Best LG, Cole SA, Domingo-Relloso A, Fretts A, Goessler W, Moon KA, Navas-Acien A, Nigra AE, Tellez-Plaza M, Umans JG, Valeri L, Zhao D |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1089/ars.2022.0029">https://dx.doi.org/10.1089/ars.2022.0029</a> |
| Public note |
https://dx.doi.org/10.1089/ars.2022.0029 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
