Increased body mass index predicts prolonged survival in patients with head and neck squamous cell carcinoma.

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Citation: Head & Neck. 44(2):325-331, 2022 02.PMID: 34773312Department: MedStar Georgetown University Hospital/MedStar Washington Hospital Center | Otolaryngology ResidencyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Head and Neck Neoplasms | *Neoplasm Recurrence, Local | Body Mass Index | Head and Neck Neoplasms/th [Therapy] | Humans | Obesity/co [Complications] | Obesity/ep [Epidemiology] | Prognosis | Squamous Cell Carcinoma of Head and NeckYear: 2022Local holdings: Available online from MWHC library: 1996 - presentISSN:
  • 1043-3074
Name of journal: Head & neckAbstract: BACKGROUND: Higher body mass index (BMI) may have a protective effect on survival in patients with head and neck cancer. The aim of this study was to determine the effect of BMI on overall survival (OS) in veterans with head and neck squamous cell carcinoma (HNSCC).CONCLUSIONS: Higher BMI at diagnosis may have a protective effect on OS in veterans with HNSCC. Copyright ♭ 2021 Wiley Periodicals LLC.METHODS: A cohort of 702 patients diagnosed with HNSCC between 1995 and 2019 were identified at the Washington DC Veterans Affairs Medical Center, and 342 patients were included for analysis. Records were queried for clinical-demographic data, BMI, and outcomes.RESULTS: HNSCC patients categorized as overweight or obese at time of diagnosis had a lower 3-year risk of death (p = 0.033) and improved OS (p < 0.001) compared to patients who were underweight or normal weight. The majority of locoregional recurrences occurred in patients with low or normal pretreatment BMI.All authors: Johnson BC, Maxwell JH, Nelson LL, Peesay T, Randall JA, Shearer SC, Wu ELFiscal year: FY2022Digital Object Identifier: ORCID:
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Available online from MWHC library: 1996 - present

BACKGROUND: Higher body mass index (BMI) may have a protective effect on survival in patients with head and neck cancer. The aim of this study was to determine the effect of BMI on overall survival (OS) in veterans with head and neck squamous cell carcinoma (HNSCC).

CONCLUSIONS: Higher BMI at diagnosis may have a protective effect on OS in veterans with HNSCC. Copyright ♭ 2021 Wiley Periodicals LLC.

METHODS: A cohort of 702 patients diagnosed with HNSCC between 1995 and 2019 were identified at the Washington DC Veterans Affairs Medical Center, and 342 patients were included for analysis. Records were queried for clinical-demographic data, BMI, and outcomes.

RESULTS: HNSCC patients categorized as overweight or obese at time of diagnosis had a lower 3-year risk of death (p = 0.033) and improved OS (p < 0.001) compared to patients who were underweight or normal weight. The majority of locoregional recurrences occurred in patients with low or normal pretreatment BMI.

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