MedStar Authors catalog › Details for: Molecule 16673-34-0: a new tool in our arsenal against inflammation.
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Molecule 16673-34-0: a new tool in our arsenal against inflammation.

by Lipinski, Michael J.
Citation: Journal of Cardiovascular Pharmacology. 63(4):314-5, 2014 Apr..Journal: Journal of cardiovascular pharmacology.ISSN: 0160-2446.Full author list: Lipinski MJ; Frias JC.UI/PMID: 24662491.Subject(s): Animals | *Anti-Inflammatory Agents, Non-Steroidal/tu [Therapeutic Use] | Benzamides/cs [Chemical Synthesis] | *Benzamides/tu [Therapeutic Use] | Blood Glucose/me [Metabolism] | *Carrier Proteins/ai [Antagonists & Inhibitors] | Cell Line | *Inflammasomes/ai [Antagonists & Inhibitors] | Macrophages/de [Drug Effects] | Male | Mice | *Myocardial Reperfusion Injury/dt [Drug Therapy] | Peritonitis/ci [Chemically Induced] | Peritonitis/pc [Prevention & Control] | Sulfonamides/cs [Chemical Synthesis] | *Sulfonamides/tu [Therapeutic Use]Institution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal ArticleOnline resources: Click here to access online Digital Object Identifier: (Click here) Abbreviated citation: J Cardiovasc Pharmacol. 63(4):314-5, 2014 Apr.Local Holdings: Available online from MWHC library: 1996 - present.Abstract: The NLRP3 inflammasome has been shown to modulate IL-1B and IL-18 production, both key molecular regulators of inflammation. This editorial discusses a new molecule 16673-34-0 that inhibits the NLRP3 inflammasome and decreases caspase 1 production following ischemia reperfusion or acute peritonitis in mice.

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