Molecule 16673-34-0: a new tool in our arsenal against inflammation.
Citation: Journal of Cardiovascular Pharmacology. 63(4):314-5, 2014 Apr.PMID: 24662491Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Anti-Inflammatory Agents, Non-Steroidal/tu [Therapeutic Use] | *Benzamides/tu [Therapeutic Use] | *Carrier Proteins/ai [Antagonists & Inhibitors] | *Inflammasomes/ai [Antagonists & Inhibitors] | *Myocardial Reperfusion Injury/dt [Drug Therapy] | *Sulfonamides/tu [Therapeutic Use] | Animals | Benzamides/cs [Chemical Synthesis] | Blood Glucose/me [Metabolism] | Cell Line | Macrophages/de [Drug Effects] | Male | Mice | Peritonitis/ci [Chemically Induced] | Peritonitis/pc [Prevention & Control] | Sulfonamides/cs [Chemical Synthesis]Local holdings: Available online from MWHC library: 1996 - presentISSN:- 0160-2446
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | Available | 24662491 |
Available online from MWHC library: 1996 - present
The NLRP3 inflammasome has been shown to modulate IL-1B and IL-18 production, both key molecular regulators of inflammation. This editorial discusses a new molecule 16673-34-0 that inhibits the NLRP3 inflammasome and decreases caspase 1 production following ischemia reperfusion or acute peritonitis in mice.
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